Anti-Mouse DKK1 Antibody (MOR04454) (MF914013)

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Datasheet

Overview

Catalog No.

MF914013

Description

Anti-Mouse DKK1 Antibody (MOR04454) [MOR04454] (MF914013) is a rat monoclonal antibody detecting DKK1 in ELISA. Suitable for Human and Mouse.

Species reactivity

Human, Mouse

Applications

ELISA

Host species

Rat

Isotype

IgG1, kappa

Clone ID

MOR04454

Clonality

Monoclonal

Target

Dickkopf-1, SK, hDkk-1, Dkk-1, Dickkopf-related protein 1, DKK1

Endotoxin level

Please contact with the lab for this information.

Purity

>95% as determined by SDS-PAGE.

Purification

Protein A/G purified from cell culture supernatant.

Accession

O54908

Form

Liquid

Storage buffer

0.01M PBS, pH 7.4.

Please refer to the specific buffer information in the hardcopy of datasheet or the lot-specific COA.

Product Usage Information

Application	Dilution
ELISA	1:2000-1:20000

Stability and Storage

Use a manual defrost freezer and avoid repeated freeze-thaw cycles. Store at 4°C short term (1-2 weeks). Store at -20°C 12 months. Store at -80°C long term.

Background

Dickkopf-related protein 1 (DKK1) is a ~29 kDa protein. Antagonizes canonical Wnt signaling by inhibiting LRP5/6 interaction with Wnt and by forming a ternary complex with the transmembrane protein KREMEN that promotes internalization of LRP5/6. Inhibits the pro-apoptotic function of KREMEN1 in a Wnt-independent manner, and has anti-apoptotic activity. Plays a role in limb development; attenuates Wnt signaling in the developing limb to allow normal limb patterning.

1. Chen, L. et al. (2008) The Journal of biological chemistry 283, 23364-70. PMID: 18524778

2. Causeret, F. et al. (2016) Cell death and differentiation 23, 323-32. PMID: 26206087

3. Ellwanger, K. et al. (2008) Molecular and cellular biology 28, 4875-82. PMID: 18505822

Note

For research use only.

Images

SDS-PAGE

SDS-PAGE for Anti-Mouse DKK1 Antibody (MOR04454)

References

Datasheet

Anti-Mouse DKK1 Antibody (MOR04454).pdf

Formula

Mass (g) = Concentration (mol/L) × Volume (L) × MW (g/mol)

Enter any 2 of Mass, Concentration, Volume + Molecular Weight to solve for the unknown.

Mass

Concentration

Volume

Molecular Weight *

g/mol

Formula

C₁ × V₁ = C₂ × V₂

Enter any 3 of the 4 values to solve for the unknown.

Stock Solution

C₁ (Stock Conc.)

V₁ (Stock Vol.)

Working Solution

C₂ (Working Conc.)

V₂ (Working Vol.)

Recombinant Proteins

Antibodies

Assay Kits

Anti-Mouse DKK1 Antibody (MOR04454) (MF914013)

Overview

Images

References

Datasheet

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