Anti-Human IL-17RA/IL-17R Recombinant Nanobody (SAA1266) (HV263013)

Name: Anti-Human IL-17RA/IL-17R Recombinant Nanobody (SAA1266)
Brand: abinScience
SKU: HV263013
Price: 126 USD
Availability: InStock

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Overview
Images
References
Datasheet
SDS

Overview

Catalog No.

HV263013

Description

Anti-Human CD217/IL17RA Nanobody (SAA1266) [SAA1266] (HV263013) is a alpaca monoclonal antibody detecting IL17RA in ELISA. Suitable for Human.

Species reactivity

Human

Applications

ELISA

Host species

Alpaca

Clonality

Monoclonal

Isotype

VHH-8His-Cys-tag

Clone ID

SAA1266

Target

IL17R, CDw217, IL-17RA, Interleukin-17 receptor A, IL-17 receptor A, IL17RA, CD217

Endotoxin level

Please contact with the lab for this information.

Purity

>95% as determined by SDS-PAGE.

Purification

Purified by Nickel column.

Accession

Q96F46

Form

Liquid

Storage buffer

0.01M PBS pH 7.4

Please refer to the specific buffer information in the hardcopy of datasheet or the lot-specific COA.

Product Usage Information

Application	Dilution
ELISA	1:2000-1:20000

Stability and Storage

Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.

Background

Interleukin-17 receptor A (CD217/IL17RA) is a ~96 kDa protein. Receptor for IL17A and IL17F, major effector cytokines of innate and adaptive immune system involved in antimicrobial host defense and maintenance of tissue integrity. Receptor for IL17A. Receptor for IL17F. Binds to IL17A with higher affinity than to IL17F. Binds IL17A and IL17F homodimers as part of a heterodimeric complex with IL17RC.

1. Kuestner, RE. et al. (2007) Journal of immunology (Baltimore, Md. : 1950) 179, 5462-73. PMID: 17911633

2. Yao, Z. et al. (1997) Cytokine 9, 794-800. PMID: 9367539

3. Ely, LK. et al. (2009) Nature immunology 10, 1245-51. PMID: 19838198

4. Toy, D. et al. (2006) Journal of immunology (Baltimore, Md. : 1950) 177, 36-9. PMID: 16785495

5. Wright, JF. et al. (2008) Journal of immunology (Baltimore, Md. : 1950) 181, 2799-805. PMID: 18684971

6. Puel, A. et al. (2011) Science (New York, N.Y.) 332, 65-8. PMID: 21350122

7. Boisson, B. et al. (2013) Immunity 39, 676-86. PMID: 24120361

Note

For research use only.

Images

SDS-PAGE

SDS-PAGE for Anti-Human CD217/IL17RA Nanobody (SAA1266)
Bioactivity

Detects recombinant CD217 (Catalog No: HV263011) in indirect ELISA.
Immunofluorescence

Immunofluorescence staining of Hepg2 with Alpaca monoclonal antibody (20ug/ml, overnight at 4°C), followed by Alexa Fluor-488-conjugated secondary antibody (6.5ug/ml, 50minutes at room temperature). The target protein was detected in the Cell membrane,Secreted.
Immunofluorescence

Immunofluorescence staining of THP1 with Alpaca monoclonal antibody (20ug/ml, overnight at 4°C), followed by Alexa Fluor-488-conjugated secondary antibody (6.5ug/ml, 50minutes at room temperature). The target protein was detected in the Cell membrane,Secreted.