Anti-NTRK1 Polyclonal Antibody (HY107014)

Name: Anti-NTRK1 Polyclonal Antibody
Brand: abinScience
SKU: HY107014
Price: 168 USD
Availability: InStock

Datasheet Share product Copy info

Price(USD):

Spec:

50ug
100ug

Number:

Get quote

Overview
Images
References
Datasheet
SDS

Overview

Catalog No.

HY107014

Description

Anti-NTRK1 Polyclonal Antibody (HY107014) is a rabbit polyclonal antibody detecting NTRK1 in ELISA, IHC, WB. Suitable for Human.

Highlights

●Affinity Purified — Minimal background and high purity for reliable results.
●Multi-Application — Validated across multiple applications.

Species reactivity

Human

Applications

ELISA, IHC, WB

Host species

Rabbit

Isotype

IgG

Clonality

Polyclonal

Immunogen

E. coli - derived recombinant human NTRK1 (Asp38-Phe378).

Target

High affinity nerve growth factor receptor, EC:2.7.10.1, Neurotrophic tyrosine kinase receptor type 1, TRK1-transforming tyrosine kinase protein, Tropomyosin-related kinase A, Tyrosine kinase receptor, Tyrosine kinase receptor A, Trk-A, gp140trk, p140-TrkA, NTRK1, MTC, TRK, TRKA

Endotoxin level

Please contact with the lab for this information.

Purification

Purified by antigen affinity column.

Accession

P04629

Form

Liquid

Storage buffer

0.01M PBS, pH 7.4, 50% Glycerol, 0.05% Proclin 300.

Please refer to the specific buffer information in the hardcopy of datasheet or the lot-specific COA.

Product Usage Information

Application	Dilution
ELISA	1:5000-1:20000
IHC	1:50-1:500
WB	1:500-1:2000

Stability and Storage

Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.

Background

High affinity nerve growth factor receptor (NTRK1) is a ~87 kDa protein. Receptor tyrosine kinase involved in the development and the maturation of the central and peripheral nervous systems through regulation of proliferation, differentiation and survival of sympathetic and nervous neurons. High affinity receptor for NGF which is its primary ligand. Can also bind and be activated by NTF3/neurotrophin-3. However, NTF3 only supports axonal extension through NTRK1 but has no effect on neuron survival. Upon dimeric NGF ligand-binding, undergoes homodimerization, autophosphorylation and activation.

1. Jing, S. et al. (1992) Neuron 9, 1067-79. PMID: 1281417

2. Tacconelli, A. et al. (2004) Cancer cell 6, 347-60. PMID: 15488758

3. Wehrman, T. et al. (2007) Neuron 53, 25-38. PMID: 17196528

4. Klein, R. et al. (1991) Cell 65, 189-97. PMID: 1849459

5. Hempstead, BL. et al. (1991) Nature 350, 678-83. PMID: 1850821

6. Tong, Q. et al. (2012) FASEB journal : official publication of the Federation of American Societies for Experimental Biology 26, 3811-21. PMID: 22649032

7. Anta, B. et al. (2016) The Journal of biological chemistry 291, 19132-45. PMID: 27445338

8. Barker, PA. et al. (1993) The Journal of biological chemistry 268, 15150-7. PMID: 8325889

Note

For research use only

Images