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Anti-Human CD104/ITGB4 Polyclonal Antibody (HB684014)

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Overview
Catalog No.HB684014
Description
Anti-Human CD104/ITGB4 Polyclonal Antibody (HB684014) is a rabbit polyclonal antibody detecting CD104. Suitable for Human.
Species reactivityHuman
ApplicationsELISA, IHC, WB
Host speciesRabbit
IsotypeIgG
Clonality Polyclonal
Immunogen E. coli - derived recombinant Human CD104/ITGB4 (Leu923-Cys1197).
Target CD104, GP150, ITGB4, Integrin beta-4
Endotoxin level Please contact with the lab for this information.
Purification Purified by antigen affinity column.
Accession P16144
Form Liquid
Storage buffer 0.01M PBS, pH 7.4, 50% Glycerol, 0.05% Proclin 300.

Please refer to the specific buffer information in the hardcopy of datasheet or the lot-specific COA.
Product Usage Information
Application Dilution
ELISA 1:5000-1:20000
IHC 1:50-1:500
WB 1:500-1:2000
Background

Integrin beta-4 (CD104/ITGB4) is a ~202 kDa protein. Integrin alpha-6/beta-4 is a receptor for laminin. Plays a critical structural role in the hemidesmosome of epithelial cells. Is required for the regulation of keratinocyte polarity and motility. ITGA6:ITGB4 binds to NRG1 (via EGF domain) and this binding is essential for NRG1-ERBB signaling. ITGA6:ITGB4 binds to IGF1 and this binding is essential for IGF1 signaling.

1. Ieguchi, K. et al. (2010) The Journal of biological chemistry 285, 31388-98. PMID: 20682778
2. Fujita, M. et al. (2012) The Journal of biological chemistry 287, 12491-500. PMID: 22351760
3. Cedano Prieto, DM. et al. (2017) PloS one 12, e0184285. PMID: 28873464
Note For research use only
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Formula
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Anti-Human CD104/ITGB4 Polyclonal Antibody

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