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Anti-Human aPC/Activated protein C Reference Antibody (Inuxucibart, RUO) (HY476036)

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Overview
Catalog No.HY476036
Description
Anti-Human aPC/Activated protein C Reference Antibody (Inuxucibart, RUO) (HY476036) is a human monoclonal antibody detecting PROC,aPC/Activated protein C.
Species reactivityHuman
ApplicationsELISA, FCM, Functional assay
Host speciesHuman
ClonalityMonoclonal
IsotypeIgG4, kappa
Target Activation peptide, Anticoagulant protein C, Autoprothrombin IIA, Blood coagulation factor XIV, EC:3.4.21.69, PROC, Vitamin K-dependent protein C, Vitamin K-dependent protein C heavy chain, Vitamin K-dependent protein C light chain
Endotoxin level < 10 EU/mg
Purity >95% as determined by SDS-PAGE.
Purification Protein A/G purified from cell culture supernatant.
Accession P04070
Form Liquid
Storage buffer 0.01M PBS pH 7.4.

Please refer to the specific buffer information in the hardcopy of datasheet or the lot-specific COA.

Stability and Storage Use a manual defrost freezer and avoid repeated freeze-thaw cycles. Store at 4°C short term (1-2 weeks). Store at -20°C 12 months. Store at -80°C long term from the date of receipt..
Alternate NamesCAS: 3078212-80-0
Background

Vitamin K-dependent protein C (APC/Activated protein C) is a ~52 kDa protein. Protein C is a vitamin K-dependent serine protease that regulates blood coagulation by inactivating factors Va and VIIIa in the presence of calcium ions and phospholipids. Exerts a protective effect on the endothelial cell barrier function.

1. Kovács, KB. et al. (2015) Thrombosis research 135, 718-26. PMID: 25618265
2. Cao, Q. et al. (2025) Nature 639, 816-824. PMID: 39880037
3. Ding, Q. et al. (2015) Blood 125, 2428-34. PMID: 25651845
Note For research use only.
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Formula
Mass (g) = Concentration (mol/L) × Volume (L) × MW (g/mol)
Enter any 2 of Mass, Concentration, Volume + Molecular Weight to solve for the unknown.
Mass
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Concentration
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Volume
Molecular Weight *
g/mol
Formula
C₁ × V₁ = C₂ × V₂
Enter any 3 of the 4 values to solve for the unknown.
Stock Solution
C₁ (Stock Conc.)
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V₁ (Stock Vol.)
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Working Solution
C₂ (Working Conc.)
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V₂ (Working Vol.)
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