Anti-Mouse CD274/PD-L1/B7-H1 Nanobody (SAA2056) (MV974023)

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Datasheet

Overview

Catalog No.

MV974023

Description

Anti-Mouse CD274/PD-L1/B7-H1 Nanobody (SAA2056) [SAA2056] (MV974023) is a alpaca monoclonal antibody detecting B7-H1 in ELISA, Neutralization. Suitable for Mouse.

Species reactivity

Mouse

Applications

ELISA, Neutralization

Host species

Alpaca

Isotype

VHH-8His-Cys-tag

Clone ID

SAA2056

Clonality

Monoclonal

Target

B7-H1, Programmed cell death 1 ligand 1, PDCD1 ligand 1, PDCD1L1, B7 homolog 1, PDCD1LG1, PDL1, hPD-L1, Programmed death ligand 1, B7H1, PD-L1, CD274

Endotoxin level

Please contact with the lab for this information.

Purity

>95% as determined by SDS-PAGE.

Purification

Purified by Nickel column.

Accession

Q9EP73

RRID

Anti-Mouse CD274/PD-L1/B7-H1 Nanobody (SAA2056) (abinScience Cat# MV974023, RRID:AB_3729050)

Form

Liquid

Storage buffer

0.01M PBS, pH 7.4.

Please refer to the specific buffer information in the hardcopy of datasheet or the lot-specific COA.

Product Usage Information

Application	Dilution
ELISA	1:2000-1:20000

Stability and Storage

Use a manual defrost freezer and avoid repeated freeze-thaw cycles. Store at 4°C short term (1-2 weeks). Store at -20°C 12 months. Store at -80°C long term.

Background

Programmed cell death 1 ligand 1 (CD274/PD-L1) is a ~32 kDa protein. Plays a critical role in induction and maintenance of immune tolerance to self. As a ligand for the inhibitory receptor PDCD1/PD-1, modulates the activation threshold of T-cells and limits T-cell effector response. Through a yet unknown activating receptor, may costimulate T-cell subsets that predominantly produce interleukin-10 (IL10). CD274 is the therapeutic target of atezolizumab (Tecentriq) and durvalumab (Imfinzi).

1. Tamura, H. et al. (2001) Blood 97, 1809-16. PMID: 11238124

2. Freeman, GJ. et al. (2000) The Journal of experimental medicine 192, 1027-34. PMID: 11015443

3. Wang, S. et al. (2003) The Journal of experimental medicine 197, 1083-91. PMID: 12719480

Note

For research use only.

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