| Catalog No. | HV162016 |
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| Species reactivity | Human |
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| Applications | ELISA, Bioactivity: FACS, Functional assay, Research in vivo |
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| Host species | Human |
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| Isotype | IgG2-lambda |
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| Expression system | Mammalian Cells |
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| Clonality | Monoclonal |
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| Target | FzE1, Frizzled-1, hFz1, Fz-1, FZD1 |
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| Endotoxin level | Please contact the lab for this information. |
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| Purity | >95% purity as determined by SDS-PAGE. |
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| Purification | Protein A/G purified from cell culture supernatant. |
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| Accession | Q9UP38 |
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| Form | Liquid |
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| Storage buffer | 0.01M PBS, pH 7.4. |
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| Stability and Storage | Use a manual defrost freezer and avoid repeated freeze-thaw cycles. Store at 4°C for short-term storage (1-2 weeks). Store at -20°C for up to 12 months. For long-term storage, store at -80°C. |
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| Alternate Names | OMP-18R5, 1345009-45-1 |
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| Background | Vantictumab (OMP-18R5) is a fully human IgG2 monoclonal antibody. Vantictumab inhibits Wnt pathway signaling by binding to FZD1/2/5/7/8 receptors. Vantictumab can be studied against cancers through direct actions on tumor cells, including CSCs, and effects on the stroma, such as metastatic HER2-negative breast cancer and metastatic pancreatic adenocarcinoma.
• Knockdown of the Wnt receptor Frizzled-1 (FZD1) reduces MDR1/P-glycoprotein expression in multidrug resistant leukemic cells and inhibits leukemic cell proliferation., PMID:29482174
• The low density lipoprotein receptor-1, LRP1, interacts with the human frizzled-1 (HFz1) and down-regulates the canonical Wnt signaling pathway., PMID:14739301
• Interference of Frizzled 1 (FZD1) reverses multidrug resistance in breast cancer cells through the Wnt/β-catenin pathway., PMID:22484497
• Functional and association analysis of frizzled 1 (FZD1) promoter haplotypes with femoral neck geometry., PMID:20051274
• Functional characterization of genetic variation in the Frizzled 1 (FZD1) promoter and association with bone phenotypes: more to the LRP5 story?, PMID:18715140
• Transcriptional Regulation of Frizzled-1 in Human Osteoblasts by Sp1., PMID:27695039
• Human frizzled 1 interacts with transforming Wnts to transduce a TCF dependent transcriptional response., PMID:10557084
• Oligodendroglial ring finger protein Rnf43 is an essential injury-specific regulator of oligodendrocyte maturation., PMID:34390652
• miR-135b reverses chemoresistance of non-small cell lung cancer cells by downregulation of FZD1., PMID:27643554
• FZD1 activates protein kinase C delta-mediated drug-resistance in multidrug-resistant MES-SA/Dx5 cancer cells., PMID:24814288
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| Note | For research use only. Not suitable for clinical or therapeutic use. |
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