Anti-Staphylococcus aureus SpA/Protein A Reference Antibody (Omodenbamab, RUO) (JN961016)

Name: Anti-Staphylococcus aureus SpA/Protein A Reference Antibody (Omodenbamab, RUO)
Brand: abinScience
SKU: JN961016
Price: 176 USD
Availability: InStock

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Overview

Catalog No.	JN961016
Description	Omodenbamab (JN961016) is a research-grade recombinant antibody targeting SpA. Produced in mammalian cells with native-like glycosylation. Highlights ●Research Grade — For PK/PD studies, assay development, and ADA research. ●Native Glycosylation — Mammalian expression ensures native-like patterns.
Species reactivity	Staphylococcus aureus
Applications	ELISA, Bioactivity: FACS, Functional assay, Research in vivo
Host species	Human
Isotype	IgG3-Kappa
Expression system	Mammalian cells
Clonality	Monoclonal
Target	SpA
Endotoxin level	< 10 EU/mg
Purity	>95% purity as determined by SDS-PAGE.
Purification	Protein A/G purified from cell culture supernatant.
Accession	P02976
Form	Liquid
Storage buffer	0.01M PBS pH 7.4 Please refer to the specific buffer information in the hardcopy of datasheet or the lot-specific COA.
Stability and Storage	Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.
Alternate Names	514-G-3, 514-G3, PA8-G3, 2241724-48-9
Background	Immunoglobulin G-binding protein A (SpA) is a ~56 kDa protein. Plays a role in the inhibition of the host innate and adaptive immune responses. Possesses five immunoglobulin-binding domains that capture both the fragment crystallizable region (Fc region) and the Fab region (part of Ig that identifies antigen) of immunoglobulins. In turn, Staphylococcus aureus is protected from phagocytic killing via inhibition of Ig Fc region. In addition, the host elicited B-cell response is prevented due to a decrease of antibody-secreting cell proliferation that enter the bone marrow, thereby decreasing long-term antibody production. Inhibits osteogenesis by preventing osteoblast proliferation and expression of alkaline phosphatase, type I collagen, osteopontin and osteocalcin. 1. Graille, M. et al. (2000) Proceedings of the National Academy of Sciences of the United States of America 97, 5399-404. PMID: 10805799 2. Moks, T. et al. (1986) European journal of biochemistry 156, 637-43. PMID: 2938951 3. Forsgren, A. et al. (1966) Journal of immunology (Baltimore, Md. : 1950) 97, 822-7. PMID: 4163007
Note	For research use only. Not suitable for clinical or therapeutic use.

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SDS-PAGE for Research Grade Omodenbamab

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Datasheet

Anti-Staphylococcus aureus SpA/Protein A Reference Antibody (Omodenbamab, RUO).pdf

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Anti-Staphylococcus aureus SpA/Protein A Reference Antibody (Omodenbamab, RUO) (JN961016)

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References

Datasheet

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