Anti-ADAMTS5 Polyclonal Antibody (HV374014)

Name: Anti-ADAMTS5 Polyclonal Antibody
Brand: abinScience
SKU: HV374014
Price: 168 USD
Availability: InStock

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Overview
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References
Datasheet
SDS

Overview

Catalog No.

HV374014

Description

Anti-ADAMTS5 Polyclonal Antibody (HV374014) is a rabbit polyclonal antibody detecting ADAMTS5 in ELISA, IHC, WB. Suitable for Human, Mouse, and Bovine.

Highlights

●Affinity Purified — Minimal background and high purity for reliable results.
●Multi-Application — Validated across multiple applications.
●Multi-Species — Cross-reactive for translational research.

Species reactivity

Human, Mouse

Applications

ELISA, IHC, WB

Host species

Rabbit

Isotype

IgG

Clonality

Polyclonal

Immunogen

E. coli - derived recombinant Human ADAMTS5 (Glu485-Pro622).

Target

ADAMTS11, ADAM-TS 11, A disintegrin and metalloproteinase with thrombospondin motifs 11, ADAMTS-11, ADMP2, ADAM-TS 5, ADAMTS-5, ADMP-2, ADAMTS5, Aggrecanase-2, ADAM-TS5, A disintegrin and metalloproteinase with thrombospondin motifs 5

Purification

Purified by antigen affinity column.

Accession

Q9UNA0

Form

Liquid

Storage buffer

0.01M PBS, pH 7.4, 50% Glycerol, 0.05% Proclin 300.

Please refer to the specific buffer information in the hardcopy of datasheet or the lot-specific COA.

Product Usage Information

Application	Dilution
ELISA	1:5000-1:20000
IHC	1:50-1:500
WB	1:500-1:2000

Stability and Storage

Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.

Background

A disintegrin and metalloproteinase with thrombospondin motifs 5 (ADAMTS5) is a ~101 kDa protein. Metalloproteinase that plays an important role in connective tissue organization, development, inflammation and cell migration. Extracellular matrix (ECM) degrading enzyme that show proteolytic activity toward the hyalectan group of chondroitin sulfate proteoglycans (CSPGs) including ACAN, VCAN, BCAN and NCAN. Cleavage within the hyalectans occurs at Glu-Xaa recognition motifs. Plays a role in embryonic development, including limb and cardiac morphogenesis, and skeletal muscle development through its VCAN remodeling properties. Cleaves VCAN in the pericellular matrix surrounding myoblasts, facilitating myoblast contact and fusion which is required for skeletal muscle development and regeneration.

1. Nakada, M. et al. (2005) Acta neuropathologica 110, 239-46. PMID: 16133547

2. Longpré, JM. et al. (2009) The international journal of biochemistry & cell biology 41, 1116-26. PMID: 18992360

Note

For research use only.

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References

Datasheet