Anti-Human ADAMTS5 Recombinant Antibody (7B4) (HV374023)

Name: Anti-Human ADAMTS5 Recombinant Antibody (7B4)
Brand: abinScience
SKU: HV374023
Price: 191 USD
Availability: InStock

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50ug
100ug
1mg

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Overview
Images
References
Datasheet
SDS

Overview

Catalog No.

HV374023

Species reactivity

Human

Applications

ELISA, Neutralization

Host species

Mouse

Isotype

IgG1

Clone ID

7B4

Clonality

Monoclonal

Target

ADAMTS5, ADAM-TS 5, ADAM-TS5, ADAMTS-5, ADAMTS11, ADAM-TS 11, ADAMTS-11, ADMP2, ADMP-2, A disintegrin and metalloproteinase with thrombospondin motifs 5, A disintegrin and metalloproteinase with thrombospondin motifs 11, Aggrecanase-2

Endotoxin level

Please contact with the lab for this information.

Purity

>95% as determined by SDS-PAGE.

Associated products

pH 7.4 Dilution Buffer

Purification

Protein A/G purified from cell culture supernatant.

Accession

Q9UNA0

RRID

Anti-Human ADAMTS5 Antibody (7B4) (abinScience Cat# HV374023, RRID:AB_3725376)

Form

Liquid

Storage buffer

0.01M PBS pH 7.4

Please refer to the specific buffer information in the hardcopy of datasheet or the lot-specific COA.

Product Usage Information

Application	Dilution
ELISA	1:2000-1:20000

Stability and Storage

Use a manual defrost freezer and avoid repeated freeze-thaw cycles. Store at 4°C short term (1-2 weeks). Store at -20°C 12 months. Store at -80°C long term.

Background

A disintegrin and metalloproteinase with thrombospondin motifs 5 (ADAMTS5) is a ~101 kDa protein. Metalloproteinase that plays an important role in connective tissue organization, development, inflammation and cell migration. Extracellular matrix (ECM) degrading enzyme that show proteolytic activity toward the hyalectan group of chondroitin sulfate proteoglycans (CSPGs) including ACAN, VCAN, BCAN and NCAN. Cleavage within the hyalectans occurs at Glu-Xaa recognition motifs. Plays a role in embryonic development, including limb and cardiac morphogenesis, and skeletal muscle development through its VCAN remodeling properties. Cleaves VCAN in the pericellular matrix surrounding myoblasts, facilitating myoblast contact and fusion which is required for skeletal muscle development and regeneration.

1. Nakada, M. et al. (2005) Acta neuropathologica 110, 239-46. PMID: 16133547

2. Longpré, JM. et al. (2009) The international journal of biochemistry & cell biology 41, 1116-26. PMID: 18992360

Note

For research use only.

Images

SDS-PAGE

SDS-PAGE for Anti-Human ADAMTS5 Antibody (7B4)

References

Datasheet

Anti-Human ADAMTS5 Recombinant Antibody (7B4).pdf

Download SDS PDF

Formula

Mass (g) = Concentration (mol/L) × Volume (L) × MW (g/mol)

Enter any 2 of Mass, Concentration, Volume + Molecular Weight to solve for the unknown.

Mass

Concentration

Volume

Molecular Weight *

g/mol

Formula

C₁ × V₁ = C₂ × V₂

Enter any 3 of the 4 values to solve for the unknown.

Stock Solution

C₁ (Stock Conc.)

V₁ (Stock Vol.)

Working Solution

C₂ (Working Conc.)

V₂ (Working Vol.)

Recombinant Proteins

Antibodies

Assay Kits

Anti-Human ADAMTS5 Recombinant Antibody (7B4) (HV374023)

Overview

Images

References

Datasheet

SDS

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