Anti-Human ADAMTS5 Reference Antibody (CRB0017, RUO) (HV374036)

Name: Anti-Human ADAMTS5 Reference Antibody (CRB0017, RUO)
Brand: abinScience
SKU: HV374036
Price: 370 USD
Availability: InStock

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Overview

Catalog No.	HV374036
Species reactivity	Human
Applications	ELISA, Bioactivity: FACS, Functional assay, Research in vivo
Host species	Human
Isotype	IgG
Clone ID	CRB0017
Biological activity	CRB0017 (1.2-12 mg per knee; intra-articular administration; 2 doses total, with a 6-week interval) significantly reduces all histopathological osteoarthritis (OA) scores in male STR/ort mice at the dose of 12 mg per knee [1].
Expression system	Mammalian cells
Clonality	Monoclonal
Target	ADAMTS11, ADAM-TS 11, A disintegrin and metalloproteinase with thrombospondin motifs 11, ADAMTS-11, ADMP2, ADAM-TS 5, ADAMTS-5, ADMP-2, ADAMTS5, Aggrecanase-2, ADAM-TS5, A disintegrin and metalloproteinase with thrombospondin motifs 5
Endotoxin level	Please contact the lab for this information.
Purity	>95% purity as determined by SDS-PAGE.
Purification	Protein A/G purified from cell culture supernatant.
Accession	Q9UNA0
Form	Liquid
Storage buffer	0.01M PBS pH 7.4 Please refer to the specific buffer information in the hardcopy of datasheet or the lot-specific COA.
Stability and Storage	Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.
Alternate Names	CRB0017
Background	A disintegrin and metalloproteinase with thrombospondin motifs 5 (ADAMTS5) is a ~101 kDa protein. Metalloproteinase that plays an important role in connective tissue organization, development, inflammation and cell migration. Extracellular matrix (ECM) degrading enzyme that show proteolytic activity toward the hyalectan group of chondroitin sulfate proteoglycans (CSPGs) including ACAN, VCAN, BCAN and NCAN. Cleavage within the hyalectans occurs at Glu-Xaa recognition motifs. Plays a role in embryonic development, including limb and cardiac morphogenesis, and skeletal muscle development through its VCAN remodeling properties. Cleaves VCAN in the pericellular matrix surrounding myoblasts, facilitating myoblast contact and fusion which is required for skeletal muscle development and regeneration. 1. Nakada, M. et al. (2005) Acta neuropathologica 110, 239-46. PMID: 16133547 2. Longpré, JM. et al. (2009) The international journal of biochemistry & cell biology 41, 1116-26. PMID: 18992360
References	1. Chiusaroli R, et al. Targeting of ADAMTS5's ancillary domain with the recombinant mAb CRB0017 ameliorates disease progression in a spontaneous murine model of osteoarthritis. Osteoarthritis Cartilage. 2013;21(11):1807-1810. [HV374036]
Note	For research use only. Not suitable for clinical or therapeutic use.