Anti-CAV1 Polyclonal Antibody (HX089014) is a rabbit polyclonal antibody detecting CAV1 in ELISA, IHC, WB. Suitable for Human, Mouse, Dog, Cat, and Rat.
Highlights
●Affinity Purified — Minimal background and high purity for reliable results.
●Multi-Application — Validated across multiple applications.
●Multi-Species — Cross-reactive for translational research.
Please refer to the specific buffer information in the hardcopy of datasheet or the lot-specific COA.
Product Usage Information
Application
Dilution
ELISA
1:5000-1:20000
IHC
1:50-1:500
WB
1:500-1:2000
Stability and Storage
Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.
Background
Caveolin-1 (CAV1) is a ~20 kDa protein. May act as a scaffolding protein within caveolar membranes. Forms a stable heterooligomeric complex with CAV2 that targets to lipid rafts and drives caveolae formation. Mediates the recruitment of CAVIN proteins (CAVIN1/2/3/4) to the caveolae. Interacts directly with G-protein alpha subunits and can functionally regulate their activity. Involved in the costimulatory signal essential for T-cell receptor (TCR)-mediated T-cell activation.
1. Vargas, L. et al. (2002) The Journal of biological chemistry 277, 9351-7. PMID: 11751885
2. McMahon, KA. et al. (2009) The EMBO journal 28, 1001-15. PMID: 19262564
3. Ohnuma, K. et al. (2007) The Journal of biological chemistry 282, 10117-10131. PMID: 17287217
4. Hwangbo, C. et al. (2016) Oncogene 35, 389-401. PMID: 25893292
Note
For research use only.
Images
Western blot
Western blot analysis was performed using anti-CAV1 polyclonal antibody at 1ug/mL on recombinant CAV1 (Catalog No. HX089012).
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