Anti-Human IL-18 R alpha Polyclonal Antibody (HC691014)

Name: Anti-Human IL-18 R alpha Polyclonal Antibody
Brand: abinScience
SKU: HC691014
Price: 168 USD
Availability: InStock

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Overview
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References
Datasheet
SDS

Overview

Catalog No.

HC691014

Description

Anti-CD218a/IL18R1 Polyclonal Antibody (HC691014) is a rabbit polyclonal antibody detecting CD218a in ELISA, IHC, WB. Suitable for Human.

Highlights

●Affinity Purified — Minimal background and high purity for reliable results.
●Multi-Application — Validated across multiple applications.

Species reactivity

Human

Applications

ELISA, IHC, WB

Host species

Rabbit

Clonality

Polyclonal

Isotype

IgG

Immunogen

E. coli - derived recombinant Human CD218a/IL18R1 (Thr147-Asn255).

Target

CD218a, IL-18R1, IL18R1, CDw218a, IL-18R-alpha, IL-18R-1, Interleukin-18 receptor 1, IL-18Ralpha, IL1 receptor-related protein, CD218 antigen-like family member A, IL-1Rrp, IL1RRP, IL1R-rp, Interleukin-18 receptor alpha

Endotoxin level

Please contact with the lab for this information.

Purity

>95% as determined by SDS-PAGE.

Purification

Purified by antigen affinity column.

Accession

Q13478

Form

Liquid

Storage buffer

0.01M PBS, pH 7.4, 50% Glycerol, 0.05% Proclin 300.

Please refer to the specific buffer information in the hardcopy of datasheet or the lot-specific COA.

Product Usage Information

Application	Dilution
ELISA	1:5000-1:20000
IHC	1:50-1:500
WB	1:500-1:2000

Stability and Storage

Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.

Background

Interleukin-18 receptor 1 (CD218a/IL18R1) is a ~62 kDa protein. Within the IL18 receptor complex, responsible for the binding of the pro-inflammatory cytokine IL18, but not IL1A nor IL1B. Involved in IL18-mediated IFNG synthesis from T-helper 1 (Th1) cells. Contributes to IL18-induced cytokine production, either independently of SLC12A3, or as a complex with SLC12A3.

1. Kato, Z. et al. (2003) Nature structural biology 10, 966-71. PMID: 14528293

2. Wei, H. et al. (2014) FEBS letters 588, 3838-43. PMID: 25261253

3. Tsutsumi, N. et al. (2014) Nature communications 5, 5340. PMID: 25500532

4. Shi, X. et al. (2023) Nature 624, 442-450. PMID: 37993714

5. Parnet, P. et al. (1996) The Journal of biological chemistry 271, 3967-70. PMID: 8626725

6. Tominaga, K. et al. (2000) International immunology 12, 151-60. PMID: 10653850

Note

For research use only.

Images

References

Datasheet

Anti-Human IL-18 R alpha Polyclonal Antibody.pdf

Download SDS PDF

Formula

Mass (g) = Concentration (mol/L) × Volume (L) × MW (g/mol)

Enter any 2 of Mass, Concentration, Volume + Molecular Weight to solve for the unknown.

Mass

Concentration

Volume

Molecular Weight *

g/mol

Formula

C₁ × V₁ = C₂ × V₂

Enter any 3 of the 4 values to solve for the unknown.

Stock Solution

C₁ (Stock Conc.)

V₁ (Stock Vol.)

Working Solution

C₂ (Working Conc.)

V₂ (Working Vol.)

Recombinant Proteins

Antibodies

Assay Kits

Anti-Human IL-18 R alpha Polyclonal Antibody (HC691014)

Overview

Images

References

Datasheet

SDS