Anti-CD49f/ITGA6 Polyclonal Antibody (HB157024)

Name: Anti-CD49f/ITGA6 Polyclonal Antibody
Brand: abinScience
SKU: HB157024
Price: 96 USD
Availability: InStock

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20ug
50ug
100ug

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References
Datasheet
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Overview

Catalog No.

HB157024

Species reactivity

Human, Mouse, Rat

Applications

ELISA, IHC, WB

Host species

Rabbit

Isotype

IgG

Clonality

Polyclonal

Immunogen

E. coli - derived recombinant Human CD49f/ITGA6 (Val463-Asp1011).

Target

CD49 antigen-like family member F, Integrin alpha-6, ITGA6, VLA-6, CD49f, Alpha6p

Purification

Purified by antigen affinity column.

Accession

P23229

Form

Liquid

Storage buffer

0.01M PBS, pH 7.4, 50% Glycerol, 0.05% Proclin 300.

Please refer to the specific buffer information in the hardcopy of datasheet or the lot-specific COA.

Product Usage Information

Application	Dilution
ELISA	1:5000-1:20000
IHC	1:50-1:500
WB	1:500-1:2000

Stability and Storage

Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.

Background

Integrin alpha-6 (CD49f/ITGA6) is a ~126 kDa protein. Integrin alpha-6/beta-1 (ITGA6:ITGB1) is a receptor for laminin on platelets. Integrin alpha-6/beta-1 (ITGA6:ITGB1) is present in oocytes and is involved in sperm-egg fusion. Integrin alpha-6/beta-4 (ITGA6:ITGB4) is a receptor for laminin in epithelial cells and it plays a critical structural role in the hemidesmosome. ITGA6:ITGB4 binds to NRG1 (via EGF domain) and this binding is essential for NRG1-ERBB signaling. ITGA6:ITGB4 binds to IGF1 and this binding is essential for IGF1 signaling.

1. Ieguchi, K. et al. (2010) The Journal of biological chemistry 285, 31388-98. PMID: 20682778

2. Fujita, M. et al. (2012) The Journal of biological chemistry 287, 12491-500. PMID: 22351760

3. Cedano Prieto, DM. et al. (2017) PloS one 12, e0184285. PMID: 28873464

Note

For research use only.

Images

Western blot

Western blot analysis was performed using anti-ITGA6 polyclonal antibody at 1ug/mL on various samples.
Lane 1: Mouse spleen lysate
Lane 2: Mouse lung lysate
Lane 3: Mouse skin lysate
Lane 4: Rat kidney lysate
Lane 5: Rat lung lysate
Lane 6: Rat skin lysate

References

Datasheet

Anti-CD49f/ITGA6 Polyclonal Antibody.pdf

Download SDS PDF

Formula

Mass (g) = Concentration (mol/L) × Volume (L) × MW (g/mol)

Enter any 2 of Mass, Concentration, Volume + Molecular Weight to solve for the unknown.

Mass

Concentration

Volume

Molecular Weight *

g/mol

Formula

C₁ × V₁ = C₂ × V₂

Enter any 3 of the 4 values to solve for the unknown.

Stock Solution

C₁ (Stock Conc.)

V₁ (Stock Vol.)

Working Solution

C₂ (Working Conc.)

V₂ (Working Vol.)

Recombinant Proteins

Antibodies

Assay Kits

Anti-CD49f/ITGA6 Polyclonal Antibody (HB157024)

Overview

Images

References

Datasheet

SDS

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