Anti-Human CD112/Nectin-2/PVRL2 Recombinant Nanobody (SAA2117) (HV456033)

Name: Anti-Human CD112/Nectin-2/PVRL2 Recombinant Nanobody (SAA2117)
Brand: abinScience
SKU: HV456033
Price: 126 USD
Availability: InStock

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Overview
Images
References
Datasheet
SDS

Overview

Catalog No.

HV456033

Description

Anti-Human CD112/Nectin-2/PVRL2 Nanobody (SAA2117) [SAA2117] (HV456033) is a alpaca monoclonal antibody detecting Nectin-2 in ELISA. Suitable for Human.

Species reactivity

Human

Applications

ELISA

Host species

Alpaca

Isotype

VHH-8His-Cys-tag

Clone ID

SAA2117

Clonality

Monoclonal

Target

NECTIN2, HVEB, PRR2, PVRL2, Nectin-2, CD112, Herpes virus entry mediator B, Herpesvirus entry mediator B, HveB, Nectin cell adhesion molecule 2 receptor-related protein 2

Endotoxin level

Please contact with the lab for this information.

Purity

>95% as determined by SDS-PAGE.

Purification

Purified by Nickel column.

Accession

Q92692

Form

Liquid

Storage buffer

0.01M PBS pH 7.4

Please refer to the specific buffer information in the hardcopy of datasheet or the lot-specific COA.

Product Usage Information

Application	Dilution
ELISA	1:2000-1:20000

Stability and Storage

Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.

Background

Nectin-2 (CD112/PVRL2) is a ~57 kDa protein. Modulator of T-cell signaling. Can be either a costimulator of T-cell function, or a coinhibitor, depending on the receptor it binds to. Upon binding to CD226, stimulates T-cell proliferation and cytokine production, including that of IL2, IL5, IL10, IL13, and IFNG. Upon interaction with PVRIG, inhibits T-cell proliferation. These interactions are competitive.

1. Zhu, Y. et al. (2016) The Journal of experimental medicine 213, 167-76. PMID: 26755705

2. Warner, MS. et al. (1998) Virology 246, 179-89. PMID: 9657005

Note

For research use only.

Images

SDS-PAGE

SDS-PAGE for Anti-Human CD112/Nectin-2/PVRL2 Nanobody (SAA2117).
Bioactivity

Detects recombinant human CD112 (Catalog No: HV456011) in indirect ELISA