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Anti-Human TRAILR1/TNFRSF10A Recombinant Antibody (SAA0083) (HT017107)

Anti-Human TRAILR1/TNFRSF10A Recombinant Antibody (SAA0083)
Anti-Human TRAILR1/TNFRSF10A Recombinant Antibody (SAA0083)
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Overview
Catalog No.HT017107
Species reactivityHuman
ApplicationsFCM
Host speciesHuman
IsotypeIgG1
Clone IDSAA0083
Clonality Monoclonal
Target TNF-related apoptosis-inducing ligand receptor 1, APO2, Death receptor 4, TRAIL receptor 1, TRAIL-R1, CD261, DR4, TRAILR1, TNFRSF10A, Tumor necrosis factor receptor superfamily member 10A
Endotoxin level Please contact with the lab for this information.
Purity >95% as determined by SDS-PAGE.
Purification Protein A/G purified from cell culture supernatant.
Accession O00220
Form Liquid
Storage buffer 0.01M PBS pH 7.4

Please refer to the specific buffer information in the hardcopy of datasheet or the lot-specific COA.

Stability and Storage Use a manual defrost freezer and avoid repeated freeze-thaw cycles. Store at 4°C short term (1-2 weeks). Store at -20°C 12 months. Store at -80°C long term.
Background

Tumor necrosis factor receptor superfamily member 10A (CD261/TNFRSF10A) is a ~50 kDa protein. Receptor for the cytotoxic ligand TNFSF10/TRAIL. The adapter molecule FADD recruits caspase-8 to the activated receptor. The resulting death-inducing signaling complex (DISC) performs caspase-8 proteolytic activation which initiates the subsequent cascade of caspases (aspartate-specific cysteine proteases) mediating apoptosis. Promotes the activation of NF-kappa-B.

1. Ramamurthy, V. et al. (2015) Acta crystallographica. Section F, Structural biology communications 71, 1273-81. PMID: 26457518
2. Chyuan, IT. et al. (2024) Journal of biomedical science 31, 33. PMID: 38532423
3. Rossin, A. et al. (2009) The Biochemical journal 419, 185-92, 2 p following 192. PMID: 19090789
4. Chaudhary, PM. et al. (1997) Immunity 7, 821-30. PMID: 9430227
Note For research use only.
Images
  • Anti-Human TRAILR1/TNFRSF10A Recombinant Antibody (SAA0083)

    SDS-PAGE

    SDS-PAGE for Anti-Human CD261/TNFRSF10A/DR4 Antibody (SAA0083)

References
Formula
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