

| Catalog No. | HT017107 |
|---|---|
| Species reactivity | Human |
| Applications | FCM |
| Host species | Human |
| Isotype | IgG1 |
| Clone ID | SAA0083 |
| Clonality | Monoclonal |
| Target | TNF-related apoptosis-inducing ligand receptor 1, APO2, Death receptor 4, TRAIL receptor 1, TRAIL-R1, CD261, DR4, TRAILR1, TNFRSF10A, Tumor necrosis factor receptor superfamily member 10A |
| Endotoxin level | Please contact with the lab for this information. |
| Purity | >95% as determined by SDS-PAGE. |
| Purification | Protein A/G purified from cell culture supernatant. |
| Accession | O00220 |
| Form | Liquid |
| Storage buffer | 0.01M PBS pH 7.4 Please refer to the specific buffer information in the hardcopy of datasheet or the lot-specific COA. |
| Stability and Storage | Use a manual defrost freezer and avoid repeated freeze-thaw cycles. Store at 4°C short term (1-2 weeks). Store at -20°C 12 months. Store at -80°C long term. |
| Background | Tumor necrosis factor receptor superfamily member 10A (CD261/TNFRSF10A) is a ~50 kDa protein. Receptor for the cytotoxic ligand TNFSF10/TRAIL. The adapter molecule FADD recruits caspase-8 to the activated receptor. The resulting death-inducing signaling complex (DISC) performs caspase-8 proteolytic activation which initiates the subsequent cascade of caspases (aspartate-specific cysteine proteases) mediating apoptosis. Promotes the activation of NF-kappa-B. 1. Ramamurthy, V. et al. (2015) Acta crystallographica. Section F, Structural biology communications 71, 1273-81. PMID: 26457518 2. Chyuan, IT. et al. (2024) Journal of biomedical science 31, 33. PMID: 38532423 3. Rossin, A. et al. (2009) The Biochemical journal 419, 185-92, 2 p following 192. PMID: 19090789 4. Chaudhary, PM. et al. (1997) Immunity 7, 821-30. PMID: 9430227 |
| Note | For research use only. |

SDS-PAGE for Anti-Human CD261/TNFRSF10A/DR4 Antibody (SAA0083)




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