Anti-Human TRAILR1/TNFRSF10A Reference Antibody (Mapatumumab, RUO) (HT017016)

Name: Anti-Human TRAILR1/TNFRSF10A Reference Antibody (Mapatumumab, RUO)
Brand: abinScience
SKU: HT017016
Price: 176 USD
Availability: InStock

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Datasheet
SDS

Overview

Catalog No.	HT017016
Description	Mapatumumab (HT017016) is a research-grade recombinant antibody targeting CD261. Produced in mammalian cells with native-like glycosylation. Highlights ●Research Grade — For PK/PD studies, assay development, and ADA research. ●Native Glycosylation — Mammalian expression ensures native-like patterns.
Species reactivity	Human
Applications	ELISA, Bioactivity: FACS, Functional assay, Research in vivo
Host species	Human
Isotype	IgG1-nd
Expression system	Mammalian cells
Clonality	Monoclonal
Target	TNF-related apoptosis-inducing ligand receptor 1, APO2, Death receptor 4, TRAIL receptor 1, TRAIL-R1, CD261, DR4, TRAILR1, TNFRSF10A, Tumor necrosis factor receptor superfamily member 10A
Endotoxin level	Please contact the lab for this information.
Purity	>95% purity as determined by SDS-PAGE.
Purification	Protein A/G purified from cell culture supernatant.
Accession	O00220
Form	Liquid
Storage buffer	0.01M PBS pH 7.4 Please refer to the specific buffer information in the hardcopy of datasheet or the lot-specific COA.
Stability and Storage	Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.
Alternate Names	HGS-ETR1, TRM-1, 658052-09-6
Background	Tumor necrosis factor receptor superfamily member 10A (CD261/TNFRSF10A) is a ~50 kDa protein. Receptor for the cytotoxic ligand TNFSF10/TRAIL. The adapter molecule FADD recruits caspase-8 to the activated receptor. The resulting death-inducing signaling complex (DISC) performs caspase-8 proteolytic activation which initiates the subsequent cascade of caspases (aspartate-specific cysteine proteases) mediating apoptosis. Promotes the activation of NF-kappa-B. 1. Ramamurthy, V. et al. (2015) Acta crystallographica. Section F, Structural biology communications 71, 1273-81. PMID: 26457518 2. Chyuan, IT. et al. (2024) Journal of biomedical science 31, 33. PMID: 38532423 3. Rossin, A. et al. (2009) The Biochemical journal 419, 185-92, 2 p following 192. PMID: 19090789 4. Chaudhary, PM. et al. (1997) Immunity 7, 821-30. PMID: 9430227
Note	For research use only. Not suitable for clinical or therapeutic use.

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Bioactivity

SEC-HPLC detection for Research Grade Mapatumumab.
SDS-PAGE

SDS-PAGE for Research Grade Mapatumumab.
Western blot

Western blot analysis was performed using anti-CD261/TNFRSF10A monoclonal antibody at 1ug/mL on various samples.
Lane 1: recombinant human CD261/TNFRSF10A (Catalog No: HT017011)
Lane 2: negative control

References

Datasheet

Anti-Human TRAILR1/TNFRSF10A Reference Antibody (Mapatumumab, RUO).pdf

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Recombinant Proteins

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Anti-Human TRAILR1/TNFRSF10A Reference Antibody (Mapatumumab, RUO) (HT017016)

Overview

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References

Datasheet

SDS

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