Anti-MeV Hemagglutinin glycoprotein Polyclonal Antibody (VK654014)

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Overview

Catalog No.

VK654014

Description

Anti-MeV Hemagglutinin glycoprotein Polyclonal Antibody (VK654014) is a rabbit polyclonal antibody detecting Hemagglutinin glycoprotein. Suitable for Measles virus.

Species reactivity

Measles virus

Applications

ELISA, IHC, WB

Host species

Rabbit

Isotype

IgG

Clonality

Polyclonal

Immunogen

E. coli - derived recombinant MeV Hemagglutinin glycoprotein (Arg59-Arg617).

Target

H, Hemagglutinin glycoprotein

Endotoxin level

Please contact with the lab for this information.

Purification

Purified by antigen affinity column.

Accession

P35971

Form

Liquid

Storage buffer

0.01M PBS, pH 7.4, 50% Glycerol, 0.05% Proclin 300.

Please refer to the specific buffer information in the hardcopy of datasheet or the lot-specific COA.

Product Usage Information

Application	Dilution
ELISA	1:5000-1:20000
IHC	1:50-1:500
WB	1:500-1:2000

Background

Hemagglutinin glycoprotein is a ~69 kDa protein. Attaches the virus to the human SLAMF1/CD150 receptor for entry into host dendritic cells, macrophages, activated memory T cells and naive or memory B cells, thereby explaining the long immunosuppression that follows infection. In the respiratory airways, binds to the NECTIN4 receptor for entry into the host cell. Binding of H protein to the receptor induces a conformational change that allows the F protein to trigger virion/cell membranes fusion. The vaccine and laboratory-adapted strains use host CD46 as an alternate receptor. The high degree of interaction between H and CD46 results in down-regulation of the latter from the surface of infected cells, rendering them more sensitive to c3b-mediated complement lysis.

1. Erlenhöfer, C. et al. (2002) The Journal of general virology 83, 1431-1436. PMID: 12029158

Note

For research use only

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References

Datasheet