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Anti-Mouse CD243/P-Glycoprotein Recombinant Antibody (SAA0482), PE (MY466127)

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Overview
Catalog No.MY466127
Species reactivityHamster
ApplicationsELISA, FCM
Host speciesRat
IsotypeIgG1, kappa
Clone IDSAA0482
ConjugationPE
Clonality Monoclonal
Target Phospholipid transporter ABCB1, MDR1, CD243, ATP-binding cassette sub-family B member 1, ABCB1, Multidrug resistance protein 1, P-glycoprotein 1, ATP-dependent translocase ABCB1, PGY1, P-Glycoprotein, P Glycoprotein
Endotoxin level Please contact with the lab for this information.
Associated products Rat IgG1, kappa Recombinant Isotype Control Antibody (ES26-14D1.11), PE
Accession P21447
Form Liquid
Storage buffer 0.01M PBS, pH 7.4, 0.2% BSA, 0.05% Proclin 300.

Please refer to the specific buffer information in the hardcopy of datasheet or the lot-specific COA.

Stability and Storage Store at 4°C for 12 months. Protect from light. Do not freeze.
Background

ATP-dependent translocase ABCB1 (CD243) is a ~140 kDa protein. Translocates drugs and phospholipids across the membrane. Catalyzes the flop of phospholipids from the cytoplasmic to the exoplasmic leaflet of the apical membrane. Participates mainly to the flop of phosphatidylcholine, phosphatidylethanolamine, beta-D-glucosylceramides and sphingomyelins. Energy-dependent efflux pump responsible for decreased drug accumulation in multidrug-resistant cells.

1. van Helvoort, A. et al. (1996) Cell 87, 507-17. PMID: 8898203
Note For flow cytometric staining, the suggested use of this reagent is 0.5 µg per million cells in 100 µL volume. It is recommended that the reagent be titrated for optimal performance for each application. For research use only.
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