InVivoMAb Anti-Human Leptin R Antibody (9F8) (HW637010)

Name: InVivoMAb Anti-Human Leptin R Antibody (9F8)
Brand: abinScience
SKU: HW637010
Price: 370 USD
Availability: InStock

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Overview

Catalog No.	HW637010
Description	InVivoMAb Anti-Human CD295/LEPR Antibody (9F8) [9F8] (HW637010) is a mouse monoclonal antibody detecting Leptin receptor in Neutralization. Suitable for Human.
Species reactivity	Human
Applications	Neutralization
Host species	Mouse
Isotype	IgG2a, kappa
Clone ID	9F8
Clonality	Monoclonal
Target	Leptin receptor, OB-R, LEP-R, LEPR, OB receptor, OBR, HuB219, DB, CD295
Endotoxin level	Please contact with the lab for this information.
Purity	>95% as determined by SDS-PAGE.
Associated products	pH 7.4 Dilution Buffer
Purification	Protein A/G purified from cell culture supernatant.
Accession	P48357
Form	Liquid
Storage buffer	0.01M PBS pH 7.4 Please refer to the specific buffer information in the hardcopy of datasheet or the lot-specific COA.
Stability and Storage	Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.
Background	Leptin receptor (CD295/LEPR) is a ~132 kDa protein. Receptor for hormone LEP/leptin (Probable). On ligand binding, mediates LEP central and peripheral effects through the activation of different signaling pathways such as JAK2/STAT3 and MAPK cascade/FOS. In the hypothalamus, LEP acts as an appetite-regulating factor that induces a decrease in food intake and an increase in energy consumption by inducing anorexinogenic factors and suppressing orexigenic neuropeptides, also regulates bone mass and secretion of hypothalamo-pituitary-adrenal hormones. In the periphery, increases basal metabolism, influences reproductive function, regulates pancreatic beta-cell function and insulin secretion, is pro-angiogenic and affects innate and adaptive immunity. Control of energy homeostasis and melanocortin production (stimulation of POMC and full repression of AgRP transcription) is mediated by STAT3 signaling, whereas distinct signals regulate NPY and the control of fertility, growth and glucose homeostasis. 1. Carpenter, B. et al. (2012) Structure (London, England : 1993) 20, 487-97. PMID: 22405007 2. Clément, K. et al. (1998) Nature 392, 398-401. PMID: 9537324 3. Zhao, Y. et al. (2003) Biochemical and biophysical research communications 300, 247-52. PMID: 12504075 4. Cassano, S. et al. (2014) Metabolism: clinical and experimental 63, 1272-9. PMID: 25060689 5. Bennett, BD. et al. (1996) Current biology : CB 6, 1170-80. PMID: 8805376
Note	For research use only. Not suitable for clinical or therapeutic use.

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Bioactivity

Detects Human CD295/LEPR in indirect ELISAs.
SDS-PAGE

SDS-PAGE for InVivoMAb Anti-Human CD295/LEPR Antibody (9F8).

References

Datasheet

InVivoMAb Anti-Human Leptin R Antibody (9F8).pdf

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InVivoMAb Anti-Human Leptin R Antibody (9F8) (HW637010)

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