InVivoMAb Anti-Human ROR1 Antibody (2A2) (HX065010)

Name: InVivoMAb Anti-Human ROR1 Antibody (2A2)
Brand: abinScience
SKU: HX065010
Price: 370 USD
Availability: InStock

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100ug
1mg

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Overview

Catalog No.	HX065010
Description	InVivoMAb Anti-Human ROR1/NTRKR1 Antibody (2A2) [2A2] (HX065010) is a human monoclonal antibody detecting Neurotrophic tyrosine kinase in ELISA, FCM, Neutralization. Suitable for Human. Highlights ●Multi-Application — Validated across multiple applications. ●Flow Cytometry — Validated for flow cytometry applications.
Species reactivity	Human
Applications	ELISA, FCM, Neutralization
Host species	Human
Isotype	IgG1, kappa
Clone ID	2A2
Clonality	Monoclonal
Target	Neurotrophic tyrosine kinase, receptor-related 1, Inactive tyrosine-protein kinase transmembrane receptor ROR1, NTRKR1, ROR1
Endotoxin level	Please contact with the lab for this information.
Purity	>95% as determined by SDS-PAGE.
Associated products	pH 7.4 Dilution Buffer
Purification	Protein A/G purified from cell culture supernatant.
Accession	Q01973
Form	Liquid
Storage buffer	0.01M PBS pH 7.4 Please refer to the specific buffer information in the hardcopy of datasheet or the lot-specific COA.
Stability and Storage	Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.
Background	Inactive tyrosine-protein kinase transmembrane receptor ROR1 (NTRKR1) is a ~104 kDa protein. Has very low kinase activity in vitro and is unlikely to function as a tyrosine kinase in vivo. Receptor for ligand WNT5A which activate downstream NFkB signaling pathway and may result in the inhibition of WNT3A-mediated signaling. In inner ear, crucial for spiral ganglion neurons to innervate auditory hair cells. Via IGFBP5 ligand, forms a complex with ERBB2 to enhance CREB oncogenic signaling. 1. Bainbridge, TW. et al. (2014) PloS one 9, e102695. PMID: 25029443 2. Diaz-Horta, O. et al. (2016) Proceedings of the National Academy of Sciences of the United States of America 113, 5993-8. PMID: 27162350 3. Lin, W. et al. (2023) Nature communications 14, 1578. PMID: 36949068
Note	For research use only. Not suitable for clinical or therapeutic use.