Human Nectin-2/CD112 Recombinant Protein (C-Fc) (HV456021)

Name: Human Nectin-2/CD112 Recombinant Protein (C-Fc)
Brand: abinScience
SKU: HV456021
Price: 298 USD
Availability: InStock

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Overview

Catalog No.	HV456021
Description	Recombinant Human CD112/Nectin-2/PVRL2 Protein, C-Fc (HV456021) expressed in Mammalian Cells, spanning Met1-Pro350. Purity: >90% by SDS-PAGE. Highlights ●Fc Fusion — Enhanced stability with Protein A/G purification compatibility. ●Mammalian Expression — Proper folding and native glycosylation. ●High Purity — >90% purity verified by SDS-PAGE.
Expression system	Mammalian cells
Accession	Q92692
Protein length	Met1-Pro350
Applications	ELISA, Immunogen, SDS-PAGE, WB, Bioactivity testing in progress
Species	Homo sapiens (Human)
Nature	Recombinant
Endotoxin level	Please contact with the lab for this information.
Purity	>90% as determined by SDS-PAGE.
Predicted molecular weight	65.22 kDa
Form	Lyophilized
Storage buffer	Lyophilized from a solution in PBS pH 7.4, 1 mM EDTA, 4% Trehalose, 1% Mannitol. Please refer to the specific buffer information in the hardcopy of datasheet or the lot-specific COA.
Reconstitution	Reconstitute in sterile water for a stock solution. A copy of datasheet will be provided with the products, please refer to it for details.
Shipping	In general, proteins are provided as lyophilized powder/frozen liquid. They are shipped out with dry ice/blue ice unless customers require otherwise.
Stability and Storage	Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.
Alternate Names	CD112, HVEB, Herpes virus entry mediator B, Herpesvirus entry mediator B, HveB, NECTIN2, Nectin cell adhesion molecule 2, Nectin-2, PRR2, PVRL2, Poliovirus receptor-related protein 2
Background	Nectin-2 is a ~57 kDa protein. Modulator of T-cell signaling. Can be either a costimulator of T-cell function, or a coinhibitor, depending on the receptor it binds to. Upon binding to CD226, stimulates T-cell proliferation and cytokine production, including that of IL2, IL5, IL10, IL13, and IFNG. Upon interaction with PVRIG, inhibits T-cell proliferation. These interactions are competitive. 1. Zhu, Y. et al. (2016) The Journal of experimental medicine 213, 167-76. PMID: 26755705 2. Warner, MS. et al. (1998) Virology 246, 179-89. PMID: 9657005
Note	For research use only

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Datasheet

Human Nectin-2/CD112 Recombinant Protein (C-Fc).pdf

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Human Nectin-2/CD112 Recombinant Protein (C-Fc) (HV456021)

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