Human IL-5 R alpha/CD125 Recombinant Protein (C-Fc) (HX243021)

Name: Human IL-5 R alpha/CD125 Recombinant Protein (C-Fc)
Brand: abinScience
SKU: HX243021
Price: 298 USD
Availability: InStock

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Overview

Catalog No.	HX243021
Description	Recombinant Human CD125/IL5RA Protein, C-Fc (HX243021) expressed in Mammalian Cells, spanning Asp21-Trp342. Purity: >90% by SDS-PAGE. Highlights ●Fc Fusion — Enhanced stability with Protein A/G purification compatibility. ●Mammalian Expression — Proper folding and native glycosylation. ●High Purity — >90% purity verified by SDS-PAGE.
Expression system	Mammalian cells
Accession	Q01344
Protein length	Asp21-Trp342
Applications	ELISA, Immunogen, SDS-PAGE, WB, Bioactivity testing in progress
Species	Homo sapiens (Human)
Nature	Recombinant
Endotoxin level	Please contact with the lab for this information.
Purity	>90% as determined by SDS-PAGE.
Predicted molecular weight	64.62 kDa
Form	Lyophilized
Storage buffer	Lyophilized from a solution in PBS pH 7.4, 1 mM EDTA, 4% Trehalose, 1% Mannitol. Please refer to the specific buffer information in the hardcopy of datasheet or the lot-specific COA.
Reconstitution	Reconstitute in sterile water for a stock solution. A copy of datasheet will be provided with the products, please refer to it for details.
Shipping	In general, proteins are provided as lyophilized powder/frozen liquid. They are shipped out with dry ice/blue ice unless customers require otherwise.
Stability and Storage	Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.
Alternate Names	CD125, CDw125, IL-5 receptor subunit alpha, IL-5R subunit alpha, IL-5R-alpha, IL-5RA, IL5R, IL5RA, Interleukin-5 receptor subunit alpha
Background	Interleukin-5 receptor subunit alpha is a ~47 kDa protein. Cell surface receptor that plays an important role in the survival, differentiation, and chemotaxis of eosinophils. Acts by forming a heterodimeric receptor with CSF2RB subunit and subsequently binding to interleukin-5. In unstimulated conditions, interacts constitutively with JAK2. Heterodimeric receptor activation leads to JAK2 stimulation and subsequent activation of the JAK-STAT pathway. 1. Monahan, J. et al. (1997) Journal of immunology (Baltimore, Md. : 1950) 159, 4024-34. PMID: 9378992 2. Tavernier, J. et al. (1992) Proceedings of the National Academy of Sciences of the United States of America 89, 7041-5. PMID: 1495999 3. Kusano, S. et al. (2012) Protein science : a publication of the Protein Society 21, 850-64. PMID: 22528658 4. Ogata, N. et al. (1998) Blood 91, 2264-71. PMID: 9516124
Note	For research use only

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Datasheet

Human IL-5 R alpha/CD125 Recombinant Protein (C-Fc).pdf

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Human IL-5 R alpha/CD125 Recombinant Protein (C-Fc) (HX243021)

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