Human CD218a/IL18R1 Recombinant Protein (C-His) (HC691021)

Name: Human CD218a/IL18R1 Recombinant Protein (C-His)
Brand: abinScience
SKU: HC691021
Price: 298 USD
Availability: InStock

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Overview

Catalog No.	HC691021
Description	Recombinant Human CD218a/IL18R1 Protein, C-His (HC691021) expressed in Mammalian Cells, spanning Ala19-Arg329. Purity: >90% by SDS-PAGE. Highlights ●His-Tagged — N-terminal 6×His tag for IMAC purification. ●Mammalian Expression — Proper folding and native glycosylation. ●High Purity — >90% purity verified by SDS-PAGE.
Expression system	Mammalian cells
Accession	Q13478
Protein length	Ala19-Arg329
Applications	ELISA, Immunogen, SDS-PAGE, WB, Bioactivity testing in progress
Species	Homo sapiens (Human)
Nature	Recombinant
Endotoxin level	Please contact with the lab for this information.
Purity	>90% as determined by SDS-PAGE.
Predicted molecular weight	38.67 kDa
Form	Lyophilized
Storage buffer	Lyophilized from a solution in PBS pH 7.4, 1 mM EDTA, 4% Trehalose, 1% Mannitol. Please refer to the specific buffer information in the hardcopy of datasheet or the lot-specific COA.
Reconstitution	Reconstitute in sterile water for a stock solution. A copy of datasheet will be provided with the products, please refer to it for details.
Shipping	In general, proteins are provided as lyophilized powder/frozen liquid. They are shipped out with dry ice/blue ice unless customers require otherwise.
Stability and Storage	Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.
Alternate Names	CD218 antigen-like family member A, CD218a, CDw218a, EC:3.2.2.6, IL-18R-1, IL-18R-alpha, IL-18R1, IL-18Ralpha, IL-1Rrp, IL1 receptor-related protein, IL18R1, IL1R-rp, IL1RRP, Interleukin-18 receptor 1, Interleukin-18 receptor alpha
Background	Interleukin-18 receptor 1 is a ~62 kDa protein. Within the IL18 receptor complex, responsible for the binding of the pro-inflammatory cytokine IL18, but not IL1A nor IL1B. Involved in IL18-mediated IFNG synthesis from T-helper 1 (Th1) cells. Contributes to IL18-induced cytokine production, either independently of SLC12A3, or as a complex with SLC12A3. 1. Kato, Z. et al. (2003) Nature structural biology 10, 966-71. PMID: 14528293 2. Wei, H. et al. (2014) FEBS letters 588, 3838-43. PMID: 25261253 3. Tsutsumi, N. et al. (2014) Nature communications 5, 5340. PMID: 25500532 4. Shi, X. et al. (2023) Nature 624, 442-450. PMID: 37993714 5. Parnet, P. et al. (1996) The Journal of biological chemistry 271, 3967-70. PMID: 8626725 6. Tominaga, K. et al. (2000) International immunology 12, 151-60. PMID: 10653850
Note	For research use only

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Datasheet

Human CD218a/IL18R1 Recombinant Protein (C-His).pdf

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Human CD218a/IL18R1 Recombinant Protein (C-His) (HC691021)

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