Mycobacterium tuberculosis Isocitrate lyase/ICL Recombinant Protein (C-Strep) (JN930022)

Name: Mycobacterium tuberculosis Isocitrate lyase/ICL Recombinant Protein (C-Strep)
Brand: abinScience
SKU: JN930022
Price: 211 USD
Availability: InStock

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Overview

Catalog No.	JN930022
Description	Recombinant Mycobacterium tuberculosis Isocitrate lyase/ICL Protein, C-Strep (JN930022) expressed in B. subtilis. Purity: >90% as determined by SDS-PAGE.. Highlights ●High Purity — >90% as determined by SDS-PAGE.
Expression system	B. subtilis
Accession	P9WKK7
Protein length	Met1-His428
Applications	ELISA, Immunogen, SDS-PAGE, WB, Bioactivity testing in progress
Species	Mycobacterium tuberculosis
Nature	Recombinant
Endotoxin level	Please contact with the lab for this information.
Purity	>90% as determined by SDS-PAGE.
Form	Lyophilized
Storage buffer	Lyophilized from a solution in PBS pH 7.4, 1 mM EDTA, 4% Trehalose, 1% Mannitol. Please refer to the specific buffer information in the hardcopy of datasheet or the lot-specific COA.
Reconstitution	Reconstitute in sterile water for a stock solution. A copy of datasheet will be provided with the products, please refer to it for details.
Shipping	In general, proteins are provided as lyophilized powder/frozen liquid. They are shipped out with dry ice/blue ice unless customers require otherwise.
Stability and Storage	Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.
Alternate Names	EC:4.1.3.1, ICL, Isocitrase, Isocitratase, Isocitrate lyase, icl
Background	Isocitrate lyase is a ~47 kDa protein. Involved in the persistence and virulence of M.tuberculosis. Catalyzes the reversible formation of succinate and glyoxylate from isocitrate, a key step of the glyoxylate cycle, which operates as an anaplerotic route for replenishing the tricarboxylic acid cycle during growth on fatty acid substrates. It could also catalyze the formation of pyruvate and succinate from 2-methylisocitrate, a key step in the methylcitrate cycle (propionate degradation route). 1. Sharma, V. et al. (2000) Nature structural biology 7, 663-8. PMID: 10932251 2. McKinney, JD. et al. (2000) Nature 406, 735-8. PMID: 10963599 3. Kumar, R. et al. (2008) Proteins 72, 892-900. PMID: 18275086 4. Moynihan, MM. et al. (2014) Biochemistry 53, 178-87. PMID: 24354272
Note	For research use only

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Mycobacterium tuberculosis Isocitrate lyase/ICL Recombinant Protein (C-Strep).pdf

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Formula

Mass (g) = Concentration (mol/L) × Volume (L) × MW (g/mol)

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C₁ × V₁ = C₂ × V₂

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Mycobacterium tuberculosis Isocitrate lyase/ICL Recombinant Protein (C-Strep) (JN930022)

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