Anti-Human CD133 Reference Antibody (CMab-43, RUO) (HT495016)

Name: Anti-Human CD133 Reference Antibody (CMab-43, RUO)
Brand: abinScience
SKU: HT495016
Price: 326 USD
Availability: InStock

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Overview

Catalog No.	HT495016
Description	Anti-Human CD133/PROM1 (CMab-43) (HT495016) is a research-grade recombinant antibody targeting CD133. Produced in mammalian cells with native-like glycosylation. Highlights ●Research Grade — For PK/PD studies, assay development, and ADA research. ●Native Glycosylation — Mammalian expression ensures native-like patterns.
Species reactivity	Human
Applications	ELISA, Bioactivity: FACS, Functional assay, Research in vivo
Host species	Human
Isotype	IgG
Clone ID	CMab-43
Expression system	Mammalian cells
Clonality	Monoclonal
Target	PROML1, PROM1, Prominin-1, Antigen AC133, CD133, Prominin-like protein 1
Endotoxin level	Please contact the lab for this information.
Purity	>95% purity as determined by SDS-PAGE.
Purification	Protein A/G purified from cell culture supernatant.
Accession	O43490
Form	Liquid
Storage buffer	0.01M PBS pH 7.4 Please refer to the specific buffer information in the hardcopy of datasheet or the lot-specific COA.
Stability and Storage	Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.
Alternate Names	CMab-43, CMab43, CMab43
Background	Prominin-1 (CD133/PROM1) is a ~97 kDa protein. May play a role in cell differentiation, proliferation and apoptosis. Binds cholesterol in cholesterol-containing plasma membrane microdomains and may play a role in the organization of the apical plasma membrane in epithelial cells. During early retinal development acts as a key regulator of disk morphogenesis. Involved in regulation of MAPK and Akt signaling pathways. In neuroblastoma cells suppresses cell differentiation such as neurite outgrowth in a RET-dependent manner. 1. Mak, AB. et al. (2014) Journal of molecular biology 426, 2175-82. PMID: 24556617 2. Takenobu, H. et al. (2011) Oncogene 30, 97-105. PMID: 20818439
Note	For research use only. Not suitable for clinical or therapeutic use.