Anti-Human Coagulation factor III/Tissue factor Reference Antibody (CNTO 860, RUO) (HB058036)

Name: Anti-Human Coagulation factor III/Tissue factor Reference Antibody (CNTO 860, RUO)
Brand: abinScience
SKU: HB058036
Price: 326 USD
Availability: InStock

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Overview

Catalog No.	HB058036
Species reactivity	Human
Applications	ELISA, Bioactivity: FACS, Functional assay, Research in vivo
Host species	Human
Isotype	IgG
Clone ID	CNTO 860
Expression system	Mammalian cells
Clonality	Monoclonal
Target	Tissue factor, CD142, F3, Thromboplastin, Coagulation factor III, TF
Endotoxin level	Please contact the lab for this information.
Purity	>95% purity as determined by SDS-PAGE.
Purification	Protein A/G purified from cell culture supernatant.
Accession	P13726
Form	Liquid
Storage buffer	0.01M PBS pH 7.4 Please refer to the specific buffer information in the hardcopy of datasheet or the lot-specific COA.
Stability and Storage	Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.
Alternate Names	CNTO-860, CNTO860, CNTO860
Background	Tissue factor (CD142/F3) is a ~33 kDa protein. Initiates blood coagulation by forming a complex with circulating factor VII or VIIa. The [TF:VIIa] complex activates factors IX or X by specific limited proteolysis. TF plays a role in normal hemostasis by initiating the cell-surface assembly and propagation of the coagulation protease cascade. CD142 is the therapeutic target of tisotumab vedotin (Tivdak).
References	1. Richard S. Tawadros, et al., CNTO 860, a humanized anti-tissue factor monoclonal antibody, significantly improves tumor response to paclitaxel in a xenograft model of colon cancer. EXPERIMENTAL AND MOLECULAR THERAPEUTICS 20: ADVANCES IN CANCER THERAPEUTICS 2006. [HB058036]
Note	For research use only. Not suitable for clinical or therapeutic use.