Anti-Human IL-31 Reference Antibody (BMS-981164, RUO) (HV678016)

Name: Anti-Human IL-31 Reference Antibody (BMS-981164, RUO)
Brand: abinScience
SKU: HV678016
Price: 176 USD
Availability: InStock

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Overview
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References
Datasheet
SDS

Overview

Catalog No.	HV678016
Species reactivity	Human
Applications	ELISA, Bioactivity: FACS, Functional assay, Research in vivo
Host species	Human
Isotype	IgG1-kappa
Clone ID	BMS-981164
Biological activity	BMS-981164 (0.01-10000 pM; 6 h) inhibits the IL-31 signaling pathway in a dose-dependent manner in PathHunter U2OS IL31RA/OSMR dimerization cells [1]. BMS-981164 (5 nM; 24 h) inhibits IL-4/IL-31-induced CCL2 secretion in human bronchial epithelial BEAS-2B cells [1].
Expression system	Mammalian cells
Clonality	Monoclonal
Target	IL-31, Interleukin-31, IL31
Endotoxin level	Please contact the lab for this information.
Purity	>95% purity as determined by SDS-PAGE.
Purification	Protein A/G purified from cell culture supernatant.
Accession	Q6EBC2
Form	Liquid
Storage buffer	0.01M PBS pH 7.4 Please refer to the specific buffer information in the hardcopy of datasheet or the lot-specific COA.
Stability and Storage	Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.
Alternate Names	BMS-981164, BMS981164, BMS981164
Background	Interleukin-31 (IL31) is a ~18 kDa protein. Activates STAT3 and possibly STAT1 and STAT5 through the IL31 heterodimeric receptor composed of IL31RA and OSMR. May function in skin immunity. Enhances myeloid progenitor cell survival in vitro. Induces RETNLA and serum amyloid A protein expression in macrophages. 1. Dillon, SR. et al. (2004) Nature immunology 5, 752-60. PMID: 15184896
References	1. Tietz J, et al. A Bispecific, Tetravalent Antibody Targeting Inflammatory and Pruritogenic Pathways in Atopic Dermatitis. JID Innov. 2024;4(2):100258. Published 2024 Jan 16. [HV678016]
Note	For research use only. Not suitable for clinical or therapeutic use.

Images

Bioactivity

Detects Recombinant Human IL31 Protein, C-His (Cat No.: HV678011) in indirect ELISA.
SDS-PAGE

SDS-PAGE for Research Grade Anti-Human IL31 (BMS-981164).