InVivoMAb™ Plus: Precision In Vivo Antibodies for Animal Models by abinScience

In vivo antibodies are critical tools for studying disease mechanisms in animal models — from tumor immunotherapy and immune checkpoint blockade to autoimmune disease intervention and cell depletion studies. However, conventional hybridoma-derived antibodies often produce inconsistent results due to Fc heterogeneity, high endotoxin levels, and batch-to-batch variability. For background on monoclonal vs polyclonal antibody production differences, see our selection guide.

abinScience's InVivoMAb™ Plus series addresses these limitations with recombinant in vivo antibodies engineered for animal model research. The portfolio covers 400+ antibodies across immune checkpoints (PD-1/PD-L1, CTLA-4, LAG-3, TIM-3, TIGIT), cell depletion (CD4, CD8, NK1.1, Ly6G), cytokine neutralization (IFN-γ, IL-2, TNF-α), and T-cell activation (CD3, CD28, CD40).

InVivoMAb™ Plus: Key Advantages Over Conventional In Vivo Antibodies

In Vivo Validation: Anti-PD-1 & Anti-PD-L1 in Syngeneic Tumor Models

The abinScience team conducted in vivo anti-tumor efficacy studies to validate the InVivoMAb™ Plus checkpoint antibodies in standard syngeneic mouse models.

Anti-PD-1: B16-F10 Melanoma Model (C57BL/6)

Fig 1. Tumor growth curves in C57BL/6 mice bearing B16-F10 melanoma treated with InVivoMAb™ Plus Anti-PD-1 antibodies (29F.1A12 and RMP1-14) vs. isotype control.

Anti-PD-L1: CT26 Colon Cancer Model (BALB/c)

Fig 2. Tumor growth curves in BALB/c mice bearing CT26 colon carcinoma treated with InVivoMAb™ Plus Anti-PD-L1 antibody (10F.9G2) vs. isotype control.

ELISA Binding Validation

To confirm target specificity and binding capacity, the InVivoMAb™ Plus PD-1 and PD-L1 antibodies were tested by direct ELISA against their respective recombinant antigens.

Fig 3. Anti-PD-1 (29F.1A12) ELISA binding to mouse PD-1 antigen.

Fig 4. Anti-PD-L1 (10F.9G2) ELISA binding to mouse PD-L1 antigen.

Application Areas

InVivoMAb™ Plus Product List

All antibodies below are carrier-free, preservative-free, endotoxin ≤1 EU/mg, purity >98%. Available in mg to gram quantities. For isotype control selection guidance, see our controls guide.

Checkpoint & Functional Antibodies

Cell Depletion Antibodies

Isotype Controls

Frequently Asked Questions

Step-by-step protocol: In Vivo Checkpoint Antibody Administration in Mouse Tumor Models on protocols.io →

All products are for research use only. For technical support, contact [email protected].