GM-CSF (granulocyte-macrophage colony-stimulating factor), encoded by the CSF2 gene, is a hematopoietic cytokine that drives the differentiation, proliferation, and activation of granulocytes and macrophages from bone marrow progenitor cells. In research, recombinant GM-CSF is a routine reagent for generating dendritic cells from monocytes in vitro — a workflow so common that most immunology labs keep a stock of GM-CSF protein alongside IL-4 for DC culture. In drug development, GM-CSF has become a major therapeutic target: anti-GM-CSF antibodies are being investigated for rheumatoid arthritis, cytokine release syndrome, and COVID-19-associated hyperinflammation.
abinScience offers 50+ GM-CSF and GM-CSF receptor products spanning recombinant proteins (human, mouse, porcine), polyclonal and recombinant detection antibodies, biosimilar reference antibodies for PK/ADA bioanalysis, an InVivoMAb-grade neutralizing antibody, and GM-CSF receptor (CD116/CD131) reagents for flow cytometry.
GM-CSF Recombinant Proteins
Carrier-free recombinant GM-CSF for DC differentiation, cell stimulation assays, ELISA standards, and immunogen use. Available in His-tagged and Fc-tagged formats across three species.
| Product Name |
Catalog No. |
Species |
Tag |
Applications |
| Human GM-CSF/CSF2 Protein | HY213012 | Human | N-His | SDS-PAGE, WB, ELISA, Immunogen |
| Human GM-CSF/CSF2 Protein | HY213022 | Human | C-His | SDS-PAGE, WB, ELISA, Immunogen |
| Human GM-CSF/CSF2 Protein | HY213011 | Human | C-His | SDS-PAGE, WB, ELISA, Immunogen |
| Mouse GM-CSF/CSF2 Protein | MY213012 | Mouse | N-His | SDS-PAGE, WB, ELISA, Immunogen |
| Mouse GM-CSF/CSF2 Protein | MY213011 | Mouse | C-His | SDS-PAGE, WB, ELISA, Immunogen |
| Porcine GM-CSF/CSF2 Protein | SY213012 | Porcine | N-His | SDS-PAGE, WB, ELISA, Immunogen |
Anti-GM-CSF Antibodies for Detection
Polyclonal antibodies for WB, IHC, and ELISA detection of GM-CSF in tissue and cell lysates, plus a recombinant antibody with flow cytometry conjugates.
Anti-GM-CSF Biosimilar Reference Antibodies
Research-grade versions of clinical-stage anti-GM-CSF therapeutic antibodies for PK/ADA bioanalytical method development, competitive binding assays, and anti-idiotype antibody screening. These are RUO products — not for clinical or diagnostic use.
| Reference Antibody |
Catalog No. |
Target |
Applications |
| Namilumab (RUO) | HY213016 | GM-CSF | ELISA, Bioactivity: FACS, Functional assay |
| Otilimab (RUO) | HY213026 | GM-CSF | ELISA, Bioactivity: FACS, Functional assay |
| Lenzilumab (RUO) | HY213036 | GM-CSF | ELISA, Bioactivity: FACS, Functional assay |
| Gimsilumab (RUO) | HY213046 | GM-CSF | ELISA, Bioactivity: FACS, Functional assay |
| Plonmarlimab (RUO) | HY213056 | GM-CSF | ELISA, Bioactivity: FACS, Functional assay |
| KB002 (RUO) | HY213066 | GM-CSF | ELISA, Bioactivity: FACS, Functional assay |
InVivoMAb Anti-GM-CSF
Endotoxin-controlled, azide-free anti-GM-CSF antibody formulated for systemic administration in animal models. Used for GM-CSF neutralization studies in autoimmune disease, transplant rejection, and cytokine storm models.
GM-CSF Receptor Reagents (CD116 & CD131)
GM-CSF signals through a heterodimeric receptor composed of a ligand-binding alpha subunit (CD116 / CSF2RA) and a signal-transducing beta subunit (CD131 / CSF2RB, shared with IL-3 and IL-5 receptors). abinScience offers recombinant receptor proteins and flow cytometry-validated antibodies for both subunits.
Additional conjugates (FITC, PE, APC, PerCP) and reference antibodies (Mavrilimumab, Trabikibart, CSL 311, Birinkibart) available — view all GM-CSF receptor products.
GM-CSF in Research: Key Applications
| DC differentiation |
Recombinant GM-CSF + IL-4 is the standard protocol for generating monocyte-derived dendritic cells (mo-DCs) from PBMCs. Typical dose: 50–100 ng/mL for 5–7 days. |
| Myeloid biology |
GM-CSF promotes survival, proliferation, and activation of granulocytes and macrophages. Used in colony-forming assays and myeloid expansion cultures. |
| Autoimmune research |
GM-CSF is implicated in rheumatoid arthritis, multiple sclerosis, and cytokine storm. Anti-GM-CSF antibodies (Namilumab, Otilimab, Lenzilumab) are being evaluated in clinical trials — our reference antibodies enable PK/ADA assay development. |
| In vivo neutralization |
InVivoMAb anti-GM-CSF (Iv0053) enables GM-CSF depletion in mouse models to study its role in inflammation, transplant rejection, and tumor immunity. |
Gene: CSF2 | UniProt: P04141 (Human) | Molecular weight: ~14.7 kDa (mature form, 127 aa) | Receptor: CSF2RA (CD116) + CSF2RB (CD131)
Exploring other cytokines?
abinScience also offers recombinant proteins and antibodies for IL-4 (pair with GM-CSF for DC culture), M-CSF/CSF1, G-CSF/CSF3, and IL-3 (shares CD131 beta subunit with GM-CSF). Contact us for help selecting the right cytokine panel.
For research use only. Not intended for diagnostic or therapeutic use.
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