Measles Virus Research Reagents — Anti-Measles Antibodies for ELISA & Neutralization

Measles is caused by Measles morbillivirus, a highly contagious negative-sense RNA virus in the family Paramyxoviridae. Despite the availability of effective vaccines (MMR), measles remains a leading cause of vaccine-preventable death globally, with resurgent outbreaks driven by declining vaccination coverage. The viral envelope glycoproteins — hemagglutinin (H) and fusion (F) — mediate receptor binding and membrane fusion, respectively, and are the primary targets for neutralizing antibodies, vaccine development, and serological diagnostics.

Research Use Only (RUO)Not intended for diagnostic or therapeutic procedures.

Measles virus structure and key research targets — hemagglutinin H protein, fusion F protein, nucleoprotein N, receptor binding and membrane fusion

Fig. 1 Measles virus structure and infection mechanism. Hemagglutinin (H) binds CD150/SLAM or Nectin-4 receptors; Fusion (F) protein mediates viral-cell membrane fusion. Key research targets highlighted in orange.

abinScience provides recombinant antibodies targeting key measles virus proteins, validated for ELISA and neutralization assays. All products are manufactured by our parent company AtaGenix Laboratories under ISO 9001 & ISO 13485 quality systems. Contact us for custom antibody development.

Key Research Targets

Hemagglutinin (H Protein) — The hemagglutinin glycoprotein mediates viral attachment by binding to host cell receptors CD150/SLAM (on immune cells) and Nectin-4 (on epithelial cells). H protein is the primary target for neutralizing antibodies and the key immunogen in measles vaccines. Anti-H antibodies support neutralization assays, vaccine immunogenicity evaluation, and receptor-binding inhibition studies.

Fusion (F Protein) — The fusion glycoprotein drives viral-host cell membrane merger following H-mediated receptor binding. F protein undergoes conformational rearrangement from a prefusion to postfusion state, making it a target for structure-guided vaccine design and fusion-inhibitor research. Anti-F antibodies enable conformational epitope studies, fusion inhibition assays, and viral entry mechanism research.

Nucleoprotein (N Protein) — The nucleoprotein encapsidates the viral RNA genome and is the most abundant viral protein in infected cells. N protein is the primary antigen used in measles IgM/IgG serological assays for diagnosis and immune status determination. Anti-N antibodies support ELISA-based serodiagnostic assay development, IFA-based viral detection, and viral replication studies.

References

1. Moss WJ. Measles. Lancet. 2017;390(10111):2490-2502. DOI

2. Hashiguchi T, Ose T, Kubota M, et al. Structure of the measles virus hemagglutinin bound to its cellular receptor SLAM. Nat Struct Mol Biol. 2011;18(2):135-141. DOI

3. Rima BK, Duprex WP. New concepts in measles virus replication: getting in and out in vivo and modulating the host cell environment. Virus Res. 2011;162(1-2):80-88. DOI

4. World Health Organization. Measles vaccines: WHO position paper — April 2017. Wkly Epidemiol Rec. 2017;92(17):205-228. Link