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In Vivo Antibodies

abinScience in vivo antibodies are functional-grade reagents optimized for animal studies—azide-free, low endotoxin, sterile-filtered and aggregation-tested. Available in blocking, depleting, and neutralizing formats with lot-specific CoA reporting purity, endotoxin (LAL), and sterility. Includes IgG, F(ab')2, and Fc-engineered options. RUO

Why Researchers Choose abinScience

Animal-Compatible Azide-free, carrier-free, sterile buffer
Low Endotoxin LAL-tested, ≤0.1 EU/μg typical
Aggregation Control SEC-HPLC/DLS verified
Flexible Formats IgG, F(ab')2, Fc variants
Lot-Specific QC CoA with endotoxin, purity, sterility

Shop by Function

Shop by Application

Selection & Handling Guide

  1. Function: Select blocking, depleting, or neutralizing based on target and desired MoA.
  2. Format: Choose IgG for Fc-mediated effects (ADCC/CDC); F(ab')2 to eliminate FcγR binding.
  3. Dosing: Follow mg/kg guidelines from literature; common routes: i.p., i.v., s.c.
  4. QC Review: Check lot CoA for endotoxin, purity, and sterility before use.
  5. Controls: Always include matched isotype and vehicle controls.

Applications

Immunotherapy mechanism studies
Cell depletion in vivo
Cytokine blockade in disease models
Vaccine efficacy and immune modulation

Documents & QC

Lot-specific CoA: concentration, endotoxin, purity, sterility
Aggregation data (SEC-HPLC/DLS)
Recommended dosing and handling protocols

FAQs

How is an in vivo antibody different from standard lab grade?

In vivo products are azide-free, low endotoxin, sterile-filtered and aggregation-controlled, with carrier-free buffers and lot-level QC tailored to animal studies.

Should I choose IgG or F(ab')2?

Use IgG for Fc effector functions (depletion/engagement); use F(ab')2 when avoiding FcγR interactions is important.

Recommended endotoxin level?

Select low-endotoxin lots per protocol and record values from the lot-specific CoA; control endotoxin alongside dose and route.

Can these be used in humans?

No. All products are for Research Use Only (RUO) and not intended for diagnostic or therapeutic use.

What is InVivo Plus?

InVivo Plus is abinScience’s premium functional-grade specification with defined buffer, endotoxin and aggregation criteria; see the dedicated page for details.

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    Antibodies (510)
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    AFP/Alpha-fetoprotein (1)
    F8/Coagulation factor VIII (7)
    IL8/CXCL8 (1)
    Fusion glycoprotein (4)
    FGF21 (1)
    CD274/PD-L1 & CD28 (1)
    PTP4A1/PRL1 (1)
    aPC/Activated protein C (3)
    FCGRT/FCRN (1)
    VP1/Coatprotein VP1 (2)
    CD307e/FCRL5 (1)
    CD152/CTLA4 & CD134/OX40 (1)
    PRLR (1)
    CSPG4/HMW-MAA/MCSP (1)
    PAUF (1)
    ANGPTL4 (2)
    CD122/IL2RB (1)
    Major surface glycoprotein G (3)
    PDGFC (1)
    Pre-F/Fusion glycoprotein F0 (2)
    Major capsid protein L1 (3)
    LGR5/GPR49 (1)
    TREM1 & CD46 (1)
    shiga toxin type 2A/stx2A (1)
    EGFR/ERBB1 & CD3E (1)
    Prefusion Protein (2)
    TSLP (1)
    CXCL1/NAP-3/GRO-alpha (1)
    NA/Neuraminidase (1)
    CCL2/MCP-1 (1)
    BMP4 (1)
    Heparanase (1)
    CD16a/FCGR3A (3)
    CCL14/NCC-2 (1)
    APOE3/4 (1)
    IL10 (1)
    Outer capsid protein VP4 (2)
    IL18/IL1F4 (1)
    C1S (1)
    RBD (Omicron/JN.1) (2)
    IL17F (1)
    GDF15/MIC1 (1)
    FedF (1)
    gp140/Env Trimer (2)
    EGFRvIII & CD3E (1)
    wlaB/pglK (1)
    TREML1/TLT1 (1)
    CD20/MS4A1 & CD3E (1)
    CLDN3/Claudin-3 (1)
    CD120b/TNFR2 (1)
    BAG3 (1)
    TCRαβ/alpha-beta TCR (1)
    ARG1/Arginase-1 (2)
    shiga toxin type 2/stx2B (1)
    OPN/SPP1 (1)
    Fc Block (1)
    GP/Glycoprotein (5)
    LTA/TNF-beta (1)
    CD340/ERBB2 (1)
    gB/BALF4 (2)
    EGFL7 (1)
    Toxin B/tcdB (1)
    TGM2 (1)
    EGFRvIII-specific/EGFR variant III (2)
    HBsAg (5)
    SAA (2)
    Protease/PR (1)
    TSHR/LGR3 (2)
    IL9 (1)
    Outer capsid glycoprotein VP7 (1)
    PSCA (1)
    MUC5AC (1)
    ROR1/NTRKR1 (1)
    CXCL9/MIG (1)
    IL13 (1)
    FAP/FAPalpha (1)
    APOE2/3/4 (1)
    Pvs25 (1)
    entB/SEB (1)
    BTN3A (1)
    IL22 (1)
    CD340/ERBB2 & CD3E (2)
    IL5 (1)
    NGF/Beta-NGF (2)
    CD279/PD-1 & CD274/PD-L1 (1)
    RBP2b (1)
    MSLN/Mesothelin (1)
    IL1B/IL1F2 (1)
    TSG101 (2)
    CD4 (1)
    ERVW-1/HERV-W-Env (1)
    CSF1/M-CSF (1)
    SFRP1 (1)
    STAT3 (1)
    CD110/TPOR (2)
    GDF11/BMP11 (1)
    VLP (1)
    SNCA/Alpha-synuclein (5)
    Envelope protein E (7)
    Fluorescein & CD274/PD-L1 (1)
    IL2 (1)
    HGF (1)
    CSF2/GM-CSF (1)
    IGF1 (2)
    GREM1/DAND2 (1)
    CD172a/SIRPA (3)
    FAP & CD3E (1)
    Glycoprotein C/Gc (2)
    CFD (1)
    LAMP5 (1)
    PTP4A3/PRL3 (1)
    sLea/CA19-9 (1)
    cyaA/Cyclolysin (2)
    Capsid protein VP1 (2)
    Fusion glycoprotein/F Trimer (1)
    CD3E (2)
    PF45/48 (2)
    IL6R (1)
    CCL8/MCP-2 (1)
    CD115/CSF1R (1)
    ACE2 (2)
    Blood group Hantigen/Globo H (3)
    VSIG4/CRIg (1)
    Mature virion in Complex [(VP0/1/3)5]12 (2)
    IFNG/IFN-gamma (2)
    BDNF (1)
    CDH17/Cadherin-17 (1)
    CD335/NCR1/NKp46 (1)
    gE/Envelope glycoprotein E (1)
    HA/Hemagglutinin (7)
    Capsid protein VP1/VP3/VP4 (2)
    THPO/Thrombopoietin (1)
    shiga toxin type 1B/stx1B (1)
    APOE (1)
    CD228/MELTF (1)
    TNFa/TNF-alpha (2)
    CD279/PD-1 & CD47/MER6 (1)
    S2 Protein (1)
    IGF2 (1)
    ADAMTS4 (4)
    F2/Prothrombin/PIVKA-II (1)
    PDGFD (1)
    IFNAR1 (1)
    CD279/PD-1 (8)
    S/Spike glycoprotein (1)
    GFRAL (1)
    IL6 (2)
    IFNB1/IFN-beta (1)
    Alpha-toxin/hly (1)
    Fluorescein & CD47/MER6 (1)
    botA/BoNT (2)
    VTCN1/B7-H4 (1)
    TRP-1 & CD134/OX40 (1)
    CD19 & CD3E (1)
    CD114/G-CSFR (1)
    IL1A/IL1F1 (1)
    CX3CL1/Fractalkine (1)
    IFNA1/Interferon alpha-D (1)
    CCL17/TARC (1)
    CD274/PD-L1 (5)
    IL23A (1)
    IL21 (1)
    IL31RA (1)
    RAGE/AGER (3)
    Spike glycoprotein 2 (5)
    ROBO2 (1)
    ADGRE1/F4/80 & CD3E (1)
    CD9 (1)
    CD274/PD-L1 & CD3E (1)
    PDGFB (1)
    CSF3/G-CSF (1)
    BMP6 (1)
    CD132/IL2RG (1)
    TGFB2/TGF-beta-2 (1)
    IFN α2/IFNA2 (1)
    CD268/TNFRSF13C (2)
    CD314/KLRK1 & CD3E (1)
    HHRF3/US28 (1)
    VSIR/VISTA & CD274/PD-L1 (1)
    APP/Amyloid beta (1)
    VEGFA (1)
    HTRA1/PRSS11 (1)
    TIGIT (3)
    BMP2 (1)
    CXCL10/IP-10 (1)
    LRRC15/LIB (1)
    RBD (13)
    CXCL12/SDF-1 (1)
    IL20 (1)
    HSP90 (1)
    ProteinUL128 & UL131A (1)
    gB/UL27 (1)
    GPA33 (1)
    IL11RA (2)
    Intermediate capsid protein VP6 (1)
    L3/CP-H/Protein II (1)
    CCL24/Eotaxin-2/MPIF-2 (1)
    TPSAB1/Tryptase-1 (1)
    CD276/B7-H3 & CD3E (1)
    gH/gL Complexes (2)
    IL36RN/IL-1F5/IL-36Ra (1)
    env/Envpolyprotein (1)
    P domain (1)
    TGFB1 (2)
    EPOR (3)
    BMP10 (1)
    TERM2 (1)
    env/Env polyprotein (4)
    CD274/PD-L1 & CD47/MER6 (1)
    CDH11 (1)
    Toxin A/tcdA (1)
    pro-MSTN/GDF8 (1)
    CD37/TSPAN26 (1)
    Flt3 ligand/FLT3LG (1)
    Procapsid [(VP0/1/3) 5] 12 (2)
    F/Fusion glycoprotein F0 (8)
    ADAMTS5 (2)
    TGFA/TGF-alpha (1)
    HBEGF (1)
    GDF2/BMP9 (1)
    mature virion in complex (5)
    F9/Factor IX (1)
    gH/Envelope glycoprotein H (2)
    NP/Nucleoprotein (3)
    CD200 & CD47/MER6 (1)
    Spike glycoprotein (1)
    Protein prM/prM (3)
    S2/Spike protein S2' (1)
    NS1/Non-structural protein 1 (1)
    Galectin-3/Gal-3 (1)
    IL31 (4)
    KLKB1/KLK3 (1)
    CD52 (1)
    CD295/LEPR (1)
    NS1 (1)
    gB/Envelope glycoprotein B (8)
    HLA-A*11:01 (1)
    S1 N-terminal domain/S1-NTD (1)
    CA9 (1)
    FOLH1/PSMA (1)
    gD/Envelope glycoprotein D (2)
    F12/Coagulationfactor XII (1)
    Capsid protein VP25 (1)
    CCL5/RANTES (1)
    SSEA4 (4)
    DPEP3 (1)
    CD79B & CD3E (1)
    SOST (1)
    GIPR/GIP-R (2)
    TIGIT & CD274/PD-L1 (1)
    LRP6 (1)
    L1/Major capsid protein L1 (2)
    ACVRL1/ALK-1 & VEGFA (1)
    CD198/CCR8 (2)
    GP/Envelopment polyprotein (1)
    CD274/PD-L1 & CD134/OX40 (1)
    CD49d/ITGA4 (1)
    Fluorescein & CD3E (1)
    CD137/4-1BB (2)
    CD152/CTLA4 & CD274/PD-L1 (1)
    TRP-1 & CD47/MER6 (1)
    CDH1/CDH11 (1)
    GP1 glycoprotein (2)
    Capsid protein VP2 (1)
    TRP-1 & CD3e (1)
    CNR1/CB1 (3)
    EPO (1)
    iga/IgA1 protease (1)
    WNT2 (2)
    E1 & E2 (gp35 & gp70) (3)
    ATTR/Transthyretin amyloidosis (4)
    IL11 (2)
    Glycoprotein G (6)
    gH/UL75 (1)
    CCL11/Eotaxin (1)
    ENT2/SLC29A2 (1)
    CD152/CTLA4 (2)
    ANGPTL3 (1)
    MUC16/CA-125 (1)
    IL17A (4)
    VWF (1)
    Tityustoxin VII/Toxin VII/Ts7 (1)
    GPC (1)
    ERBB3/HER3 (1)
    L2/Minor capsid protein L2 (2)
    APCS/PTX2 (1)
    CXCL11/I-TAC (1)
    CD20/MS4A1 (1)
    OSM/Oncostatin-M (1)
    ADM/Adrenomedullin (1)
    RSPO3 (1)
    CD73/NT5E (2)
    CD40/TNFRSF5 (1)
    Fusion glycoprotein F0 (4)
    CXCL4/PF4 (1)
    CCL3/MIP-1-alpha (1)
    CTGF/CCN2 (1)
    Neuraminidase/NA (3)
    Capsid protein (2)
    G/Major surface glycoprotein G (2)
    lukF (1)
    CD8a/Lyt2 (1)
    CD254/RANKL/TNFSF11 (1)
    GPRC5D (1)
    ApoC3 (1)
    CD16/CD32 (1)
    SOD1 (1)
    CCL1/I-309 (1)
    RBD (S6P trimer) (3)
    gp120/Glycoprotein 120 (1)
    STEAP1 (1)
    TNFSF9/4-1BBL (2)
    NS1/gp68/gp70 (6)
    CD283/TLR3 (2)
    MASP2 (1)
    APOE4 (1)
    gp125 (1)
    S-HBsAg/SHB (1)
    CD99 (1)
    IL12B/IL-12 p40 (1)
  • Species
    0 selected
    Severe acute respiratory syndrome coronavirus (SARS-CoV) (3)
    Campylobacter jejuni subsp. (1)
    Human papillomavirus 59 (HPV59) (1)
    Human (224)
    Zaire ebolavirus (ZEBOV) (6)
    Andes virus (ANDV) (2)
    Coxsackievirus B1 (CBV1) (3)
    Clostridioides difficile (2)
    Rotavirus A (RV-A) (4)
    Plasmodium vivax (2)
    Hendra virus (HeV) (2)
    Epstein-Barr virus (EBV/HHV-4) (2)
    Human endogenous retroviruses W (HERV-W) (1)
    Chikungunya virus (CHIKV) (1)
    Dengue virus type 2 (DENV-2) (9)
    Sin Nombre virus (SNV) (2)
    Bordetella pertussis (2)
    Poliovirus type 1 (PV1) (2)
    Plasmodium falciparum (2)
    General (3)
    Influenza A virus (Flu A) (9)
    Junin mammarenavirus (JUNV) (1)
    Mouse (65)
    Clostridium botulinum (2)
    Reston ebolavirus (REBOV) (1)
    Enterovirus D68 (EV-D68) (2)
    Human herpesvirus 1 (HSV-1/HHV-1) (5)
    Human cytomegalovirus (HCMV/HHV-5) (7)
    Bundibugyo ebolavirus (BDBV) (1)
    Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) (21)
    Monkey (1)
    Dengue virus type 1 (DENV-1) (1)
    Middle East respiratory syndrome-related coronavirus (MERS-CoV) (5)
    Candida albicans (1)
    Human adenovirus 3 (HAdV-3) (1)
    Varicella-zoster virus (VZV/HHV-3) (4)
    Suid alphaherpesvirus 1 (SuHV-1/PRV) (3)
    Ebola virus (EBOV) (1)
    Enterovirus 71 (EV71) (4)
    Human respiratory syncytial virus (HRSV) (14)
    Hantaan virus (HTNV) (2)
    Coxsackievirus A16 (CVA16) (2)
    Tai Forest ebolavirus (TAFV) (1)
    Human parvovirus B19 (HPV B19) (3)
    Hepatitis E virus/HEV (1)
    Dog (11)
    Dengue virus type 3 (DENV-3) (1)
    Zika virus (ZIKV) (2)
    Cat (1)
    Human astrovirus-8 (HAtVs) (1)
    Human betacoronavirus 2c EMC/2012 (HCoV-EMC) (2)
    Human papillomavirus 6 (HPV6) (1)
    Orthohantavirus puumalaense (PUUV) (1)
    Sudan ebolavirus (SEBOV) (1)
    Machupo virus (MACV) (1)
    Human hepatitis A virus (HHAV) (1)
    Puumala virus (PUUV) (2)
    Streptococcus pneumoniae (1)
    Dengue virus type 4 (DENV-4) (1)
    Brazilian scorpion (1)
    Lassa virus (LASV) (1)
    Human papillomavirus 16 (HPV16) (2)
    Nipah virus (NiV) (13)
    Porcine circovirus 2 (PCV2) (2)
    Bovine respiratory syncytial virus (BRSV) (2)
    Staphylococcus aureus (3)
    Dobrava-Belgrade virus (DOBV) (2)
    Human immunodeficiency virus 1 (HIV-1) (10)
    Hepatitis C Virus (HCV) (9)
    Hepatitis B virus genotype A (HBV-A) (6)
    Rat (1)
    Human metapneumovirus (HMPV) (5)
    Rabbit (2)
    Seoul virus (SEOV) (2)
    Human metapneumovirus (2)
    Human papillomavirus 58 (HPV58) (3)
    Japanese encephalitis virus (JEV) (1)
    Influenza B virus (Flu B) (1)
    Rotavirus (RV) (1)
    E. coli (4)
  • Applications
    0 selected
    T cell stimulation (Reported) (1)
    Agonist (8)
    Research in vivo (2)
    FuncS (55)
    in vivo (1)
    Blocking (41)
    in vivo CD4+ T cell depletion (1)
    in vivo PD-L1 blockade (3)
    T cell depletion (Reported) (1)
    FCM (77)
    in vitro PD-L1 blockade (3)
    Antagonist (1)
    IHC-F (3)
     ELISA (1)
    WB (22)
    in vivo research (1)
    IF (8)
    DB (2)
    SPR (18)
    Stimulatory (1)
    ELISA (424)
    IP (5)
    IHC (6)
    FACS (2)
    Nneutralization (1)
    RIA (1)
    Neutralization (388)
    Cell Deplete (1)
    in vivo blocking of PD-1/PD-L signaling (2)
    Functional assay (2)
    in vivo study (4)
    ICC (1)
  • Reactivity
    0 selected
    Chikungunya virus (1)
    Mouse (12)
    Puumala virus (1)
    Human (16)
    Coxsackievirus B1 (CVB1) (3)
    Influenza B virus (1)
  • Host species
    0 selected
    Alpaca (5)
    Mouse (161)
    Hamster (1)
    Human (319)
    Dog (8)
    Cat (1)
    Rat (11)
  • Clonality
    0 selected
    Monoclonal (510)
  • Conjugate
    0 selected
    Unconjugated (510)

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