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In Vivo Antibodies

abinScience in vivo antibodies are functional-grade reagents optimized for animal studies—azide-free, low endotoxin, sterile-filtered and aggregation-tested. Available in blocking, depleting, and neutralizing formats with lot-specific CoA reporting purity, endotoxin (LAL), and sterility. Includes IgG, F(ab')2, and Fc-engineered options. RUO

Why Researchers Choose abinScience

Animal-Compatible Azide-free, carrier-free, sterile buffer
Low Endotoxin LAL-tested, ≤0.1 EU/μg typical
Aggregation Control SEC-HPLC/DLS verified
Flexible Formats IgG, F(ab')2, Fc variants
Lot-Specific QC CoA with endotoxin, purity, sterility

Shop by Function

Shop by Application

Selection & Handling Guide

  1. Function: Select blocking, depleting, or neutralizing based on target and desired MoA.
  2. Format: Choose IgG for Fc-mediated effects (ADCC/CDC); F(ab')2 to eliminate FcγR binding.
  3. Dosing: Follow mg/kg guidelines from literature; common routes: i.p., i.v., s.c.
  4. QC Review: Check lot CoA for endotoxin, purity, and sterility before use.
  5. Controls: Always include matched isotype and vehicle controls.

Applications

Immunotherapy mechanism studies
Cell depletion in vivo
Cytokine blockade in disease models
Vaccine efficacy and immune modulation

Documents & QC

Lot-specific CoA: concentration, endotoxin, purity, sterility
Aggregation data (SEC-HPLC/DLS)
Recommended dosing and handling protocols

FAQs

How is an in vivo antibody different from standard lab grade?

In vivo products are azide-free, low endotoxin, sterile-filtered and aggregation-controlled, with carrier-free buffers and lot-level QC tailored to animal studies.

Should I choose IgG or F(ab')2?

Use IgG for Fc effector functions (depletion/engagement); use F(ab')2 when avoiding FcγR interactions is important.

Recommended endotoxin level?

Select low-endotoxin lots per protocol and record values from the lot-specific CoA; control endotoxin alongside dose and route.

Can these be used in humans?

No. All products are for Research Use Only (RUO) and not intended for diagnostic or therapeutic use.

What is InVivo Plus?

InVivo Plus is abinScience’s premium functional-grade specification with defined buffer, endotoxin and aggregation criteria; see the dedicated page for details.

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    Antibodies (510)
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    CLDN3/Claudin-3 (1)
    FGF21 (1)
    CD307e/FCRL5 (1)
    PRLR (1)
    IFN α2/IFNA2 (1)
    ANGPTL4 (2)
    shiga toxin type 2/stx2B (1)
    GP/Glycoprotein (5)
    CD122/IL2RB (1)
    CD340/ERBB2 (1)
    PDGFC (1)
    LGR5/GPR49 (1)
    EGFRvIII & CD3E (1)
    F8/Coagulation factor VIII (7)
    wlaB/pglK (1)
    CD20/MS4A1 & CD3E (1)
    CXCL1/NAP-3/GRO-alpha (1)
    CCL2/MCP-1 (1)
    MUC5AC (1)
    ROR1/NTRKR1 (1)
    CCL14/NCC-2 (1)
    APOE2/3/4 (1)
    IL10 (1)
    Outer capsid protein VP4 (2)
    IL18/IL1F4 (1)
    IL17F (1)
    GDF15/MIC1 (1)
    Toxin B/tcdB (1)
    TGM2 (1)
    EGFRvIII-specific/EGFR variant III (2)
    TSLP (1)
    SAA (2)
    Protease/PR (1)
    TREML1/TLT1 (1)
    NS1/Non-structural protein 1 (1)
    TSG101 (2)
    ERVW-1/HERV-W-Env (1)
    SFRP1 (1)
    VLP (1)
    BAG3 (1)
    SNCA/Alpha-synuclein (5)
    Fluorescein & CD274/PD-L1 (1)
    ARG1/Arginase-1 (2)
    OPN/SPP1 (1)
    ADAMTS5 (2)
    LTA/TNF-beta (1)
    LAMP5 (1)
    PTP4A3/PRL3 (1)
    gp140/Env Trimer (2)
    CD340/ERBB2 & CD3E (2)
    CD279/PD-1 & CD274/PD-L1 (1)
    RBP2b (1)
    CD3E (2)
    TSHR/LGR3 (2)
    PF45/48 (2)
    IL9 (1)
    Outer capsid glycoprotein VP7 (1)
    CD115/CSF1R (1)
    PSCA (1)
    CXCL9/MIG (1)
    ACE2 (2)
    IL13 (1)
    Blood group Hantigen/Globo H (3)
    Pre-F/Fusion glycoprotein F0 (2)
    FAP/FAPalpha (1)
    Pvs25 (1)
    Mature virion in Complex [(VP0/1/3)5]12 (2)
    CDH17/Cadherin-17 (1)
    entB/SEB (1)
    CD335/NCR1/NKp46 (1)
    Fusion glycoprotein (4)
    IL22 (1)
    gB/BALF4 (2)
    EGFL7 (1)
    Capsid protein VP1 (2)
    HBsAg (5)
    Fusion glycoprotein/F Trimer (1)
    aPC/Activated protein C (3)
    Heparanase (1)
    CSF1/M-CSF (1)
    IFNAR1 (1)
    STAT3 (1)
    L1/Major capsid protein L1 (2)
    GDF11/BMP11 (1)
    IFNB1/IFN-beta (1)
    Envelope protein E (7)
    Alpha-toxin/hly (1)
    Fluorescein & CD47/MER6 (1)
    botA/BoNT (2)
    HGF (1)
    TRP-1 & CD134/OX40 (1)
    CSF2/GM-CSF (1)
    CD19 & CD3E (1)
    IGF1 (2)
    GREM1/DAND2 (1)
    CFD (1)
    sLea/CA19-9 (1)
    shiga toxin type 1B/stx1B (1)
    NGF/Beta-NGF (2)
    CD279/PD-1 & CD47/MER6 (1)
    ATTR/Transthyretin amyloidosis (4)
    NA/Neuraminidase (1)
    TCRαβ/alpha-beta TCR (1)
    CCL8/MCP-2 (1)
    VSIG4/CRIg (1)
    IL31RA (1)
    IFNG/IFN-gamma (2)
    BDNF (1)
    RAGE/AGER (3)
    gE/Envelope glycoprotein E (1)
    HA/Hemagglutinin (7)
    cyaA/Cyclolysin (2)
    TNFa/TNF-alpha (2)
    CD274/PD-L1 & CD3E (1)
    IGF2 (1)
    F2/Prothrombin/PIVKA-II (1)
    CD268/TNFRSF13C (2)
    CD314/KLRK1 & CD3E (1)
    PDGFD (1)
    GFRAL (1)
    VSIR/VISTA & CD274/PD-L1 (1)
    APP/Amyloid beta (1)
    BTN3A (1)
    HTRA1/PRSS11 (1)
    TIGIT (3)
    Spike glycoprotein 2 (5)
    ROBO2 (1)
    THPO/Thrombopoietin (1)
    APOE (1)
    CD16/CD32 (1)
    CD228/MELTF (1)
    ADGRE1/F4/80 & CD3E (1)
    CD274/PD-L1 (5)
    ProteinUL128 & UL131A (1)
    gB/UL27 (1)
    L3/CP-H/Protein II (1)
    IL23A (1)
    TPSAB1/Tryptase-1 (1)
    CD172a/SIRPA (3)
    FAP & CD3E (1)
    Glycoprotein C/Gc (2)
    IL21 (1)
    CD276/B7-H3 & CD3E (1)
    MSLN/Mesothelin (1)
    CD4 (1)
    CX3CL1/Fractalkine (1)
    LRRC15/LIB (1)
    IFNA1/Interferon alpha-D (1)
    CCL17/TARC (1)
    CD110/TPOR (2)
    TERM2 (1)
    IL6R (1)
    CD274/PD-L1 & CD47/MER6 (1)
    PDGFB (1)
    CSF3/G-CSF (1)
    Toxin A/tcdA (1)
    BMP6 (1)
    pro-MSTN/GDF8 (1)
    CD132/IL2RG (1)
    TGFB2/TGF-beta-2 (1)
    IL8/CXCL8 (1)
    HHRF3/US28 (1)
    Procapsid [(VP0/1/3) 5] 12 (2)
    VP1/Coatprotein VP1 (2)
    NP/Nucleoprotein (3)
    CD200 & CD47/MER6 (1)
    VEGFA (1)
    Spike glycoprotein (1)
    Protein prM/prM (3)
    S2/Spike protein S2' (1)
    BMP2 (1)
    Galectin-3/Gal-3 (1)
    Major capsid protein L1 (3)
    NS1 (1)
    S/Spike glycoprotein (1)
    CXCL12/SDF-1 (1)
    IL20 (1)
    HSP90 (1)
    GPA33 (1)
    VTCN1/B7-H4 (1)
    HLA-A*11:01 (1)
    Intermediate capsid protein VP6 (1)
    CCL24/Eotaxin-2/MPIF-2 (1)
    CD114/G-CSFR (1)
    Capsid protein VP25 (1)
    SSEA4 (4)
    Capsid protein VP1/VP3/VP4 (2)
    gH/gL Complexes (2)
    CD79B & CD3E (1)
    SOST (1)
    IL36RN/IL-1F5/IL-36Ra (1)
    IL31 (4)
    KLKB1/KLK3 (1)
    env/Envpolyprotein (1)
    S2 Protein (1)
    CXCL10/IP-10 (1)
    CD52 (1)
    CD295/LEPR (1)
    RBD (13)
    BMP10 (1)
    CD198/CCR8 (2)
    env/Env polyprotein (4)
    CD274/PD-L1 & CD134/OX40 (1)
    CD49d/ITGA4 (1)
    Fluorescein & CD3E (1)
    CD152/CTLA4 & CD274/PD-L1 (1)
    TRP-1 & CD47/MER6 (1)
    Flt3 ligand/FLT3LG (1)
    GP1 glycoprotein (2)
    F/Fusion glycoprotein F0 (8)
    TRP-1 & CD3e (1)
    TGFA/TGF-alpha (1)
    CD120b/TNFR2 (1)
    CNR1/CB1 (3)
    HBEGF (1)
    iga/IgA1 protease (1)
    GDF2/BMP9 (1)
    WNT2 (2)
    mature virion in complex (5)
    gH/Envelope glycoprotein H (2)
    IL11 (2)
    Fc Block (1)
    TGFB1 (2)
    TIGIT & CD274/PD-L1 (1)
    LRP6 (1)
    ACVRL1/ALK-1 & VEGFA (1)
    VWF (1)
    GPC (1)
    gB/Envelope glycoprotein B (8)
    ERBB3/HER3 (1)
    CD20/MS4A1 (1)
    S1 N-terminal domain/S1-NTD (1)
    CA9 (1)
    FOLH1/PSMA (1)
    gD/Envelope glycoprotein D (2)
    F12/Coagulationfactor XII (1)
    CCL5/RANTES (1)
    RSPO3 (1)
    Fusion glycoprotein F0 (4)
    DPEP3 (1)
    CD9 (1)
    GIPR/GIP-R (2)
    Glycoprotein G (6)
    gH/UL75 (1)
    MUC16/CA-125 (1)
    Capsid protein (2)
    G/Major surface glycoprotein G (2)
    IL5 (1)
    IL11RA (2)
    CD137/4-1BB (2)
    CD254/RANKL/TNFSF11 (1)
    IL1B/IL1F2 (1)
    EPO (1)
    ApoC3 (1)
    IL2 (1)
    IL17A (4)
    Tityustoxin VII/Toxin VII/Ts7 (1)
    NS1/gp68/gp70 (6)
    CD283/TLR3 (2)
    MASP2 (1)
    APOE4 (1)
    L2/Minor capsid protein L2 (2)
    APCS/PTX2 (1)
    F9/Factor IX (1)
    gp125 (1)
    CXCL11/I-TAC (1)
    CD99 (1)
    OSM/Oncostatin-M (1)
    ADM/Adrenomedullin (1)
    P domain (1)
    CD73/NT5E (2)
    EPOR (3)
    CD40/TNFRSF5 (1)
    CXCL4/PF4 (1)
    CCL3/MIP-1-alpha (1)
    CDH11 (1)
    CCL11/Eotaxin (1)
    ENT2/SLC29A2 (1)
    CD152/CTLA4 (2)
    ANGPTL3 (1)
    CD37/TSPAN26 (1)
    RBD (S6P trimer) (3)
    CD274/PD-L1 & CD28 (1)
    PTP4A1/PRL1 (1)
    FCGRT/FCRN (1)
    lukF (1)
    CD152/CTLA4 & CD134/OX40 (1)
    CD8a/Lyt2 (1)
    ADAMTS4 (4)
    CSPG4/HMW-MAA/MCSP (1)
    PAUF (1)
    CD279/PD-1 (8)
    Major surface glycoprotein G (3)
    IL6 (2)
    GPRC5D (1)
    TREM1 & CD46 (1)
    shiga toxin type 2A/stx2A (1)
    EGFR/ERBB1 & CD3E (1)
    SOD1 (1)
    CCL1/I-309 (1)
    AFP/Alpha-fetoprotein (1)
    CTGF/CCN2 (1)
    Neuraminidase/NA (3)
    IL1A/IL1F1 (1)
    CDH1/CDH11 (1)
    BMP4 (1)
    gp120/Glycoprotein 120 (1)
    STEAP1 (1)
    TNFSF9/4-1BBL (2)
    Capsid protein VP2 (1)
    CD16a/FCGR3A (3)
    APOE3/4 (1)
    E1 & E2 (gp35 & gp70) (3)
    S-HBsAg/SHB (1)
    C1S (1)
    RBD (Omicron/JN.1) (2)
    FedF (1)
    IL12B/IL-12 p40 (1)
    GP/Envelopment polyprotein (1)
    Prefusion Protein (2)
  • Species
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    Human endogenous retroviruses W (HERV-W) (1)
    Chikungunya virus (CHIKV) (1)
    Coxsackievirus B1 (CBV1) (3)
    Human parvovirus B19 (HPV B19) (3)
    Plasmodium falciparum (2)
    Rotavirus A (RV-A) (4)
    Seoul virus (SEOV) (2)
    General (3)
    Human metapneumovirus (2)
    Plasmodium vivax (2)
    Rat (1)
    Human metapneumovirus (HMPV) (5)
    Epstein-Barr virus (EBV/HHV-4) (2)
    Poliovirus type 1 (PV1) (2)
    Rabbit (2)
    Junin mammarenavirus (JUNV) (1)
    Human papillomavirus 6 (HPV6) (1)
    Dengue virus type 2 (DENV-2) (9)
    Clostridium botulinum (2)
    Reston ebolavirus (REBOV) (1)
    Andes virus (ANDV) (2)
    Influenza A virus (Flu A) (9)
    Bordetella pertussis (2)
    Bundibugyo ebolavirus (BDBV) (1)
    Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) (21)
    Monkey (1)
    Human adenovirus 3 (HAdV-3) (1)
    Human herpesvirus 1 (HSV-1/HHV-1) (5)
    Sin Nombre virus (SNV) (2)
    Suid alphaherpesvirus 1 (SuHV-1/PRV) (3)
    Dengue virus type 1 (DENV-1) (1)
    Ebola virus (EBOV) (1)
    Human cytomegalovirus (HCMV/HHV-5) (7)
    Enterovirus 71 (EV71) (4)
    Tai Forest ebolavirus (TAFV) (1)
    Human papillomavirus 58 (HPV58) (3)
    Candida albicans (1)
    Cat (1)
    Human astrovirus-8 (HAtVs) (1)
    Enterovirus D68 (EV-D68) (2)
    Varicella-zoster virus (VZV/HHV-3) (4)
    Dog (11)
    Dengue virus type 3 (DENV-3) (1)
    Middle East respiratory syndrome-related coronavirus (MERS-CoV) (5)
    Zika virus (ZIKV) (2)
    Sudan ebolavirus (SEBOV) (1)
    Human papillomavirus 59 (HPV59) (1)
    Machupo virus (MACV) (1)
    Human respiratory syncytial virus (HRSV) (14)
    Human (224)
    Streptococcus pneumoniae (1)
    Coxsackievirus A16 (CVA16) (2)
    Lassa virus (LASV) (1)
    Nipah virus (NiV) (13)
    Dengue virus type 4 (DENV-4) (1)
    Porcine circovirus 2 (PCV2) (2)
    Bovine respiratory syncytial virus (BRSV) (2)
    Human betacoronavirus 2c EMC/2012 (HCoV-EMC) (2)
    Brazilian scorpion (1)
    Hepatitis C Virus (HCV) (9)
    Hantaan virus (HTNV) (2)
    Human papillomavirus 16 (HPV16) (2)
    Hepatitis E virus/HEV (1)
    Staphylococcus aureus (3)
    Mouse (65)
    Human immunodeficiency virus 1 (HIV-1) (10)
    Human hepatitis A virus (HHAV) (1)
    Puumala virus (PUUV) (2)
    Hepatitis B virus genotype A (HBV-A) (6)
    E. coli (4)
    Orthohantavirus puumalaense (PUUV) (1)
    Japanese encephalitis virus (JEV) (1)
    Zaire ebolavirus (ZEBOV) (6)
    Severe acute respiratory syndrome coronavirus (SARS-CoV) (3)
    Campylobacter jejuni subsp. (1)
    Influenza B virus (Flu B) (1)
    Dobrava-Belgrade virus (DOBV) (2)
    Rotavirus (RV) (1)
    Hendra virus (HeV) (2)
    Clostridioides difficile (2)
  • Applications
    0 selected
    Nneutralization (1)
    in vivo PD-L1 blockade (3)
    FACS (2)
    WB (22)
    Agonist (8)
    Blocking (41)
    in vivo study (4)
    in vitro PD-L1 blockade (3)
    ICC (1)
    Functional assay (2)
    SPR (18)
    IHC-F (3)
    ELISA (424)
    in vivo (1)
    T cell stimulation (Reported) (1)
    Research in vivo (2)
    in vivo CD4+ T cell depletion (1)
    Neutralization (388)
    T cell depletion (Reported) (1)
    DB (2)
    IF (8)
    Antagonist (1)
    IP (5)
    IHC (6)
     ELISA (1)
    RIA (1)
    Cell Deplete (1)
    FCM (77)
    in vivo research (1)
    in vivo blocking of PD-1/PD-L signaling (2)
    FuncS (55)
    Stimulatory (1)
  • Reactivity
    0 selected
    Human (16)
    Influenza B virus (1)
    Mouse (12)
    Puumala virus (1)
    Chikungunya virus (1)
    Coxsackievirus B1 (CVB1) (3)
  • Host species
    0 selected
    Alpaca (5)
    Cat (1)
    Dog (8)
    Hamster (1)
    Rat (11)
    Mouse (161)
    Human (319)
  • Clonality
    0 selected
    Monoclonal (510)
  • Conjugate
    0 selected
    Unconjugated (510)

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