Machupo Virus (MACV) Research Reagents — Antibodies & Recombinant Proteins for Bolivian Hemorrhagic Fever

Glycoprotein GP1 — Receptor-Binding & Neutralization Target
GP1 mediates viral attachment via TfR1 and is the primary target for neutralizing antibodies. Anti-GP1 antibodies can potentially cross-neutralize related New World arenaviruses (JUNV, GTOV) that share the TfR1 entry pathway. Available:
• InVivoMAb anti-GP1 clone MAC1 (VK765010) — low-endotoxin, azide-free for in vivo neutralization studies
• Recombinant GP1 proteins: C-Fc (VK765011) (ideal for Protein A capture-based assays), C-His (VK765021), N-His (VK765022), and N-His variant (VK765042)
• Polyclonal antibodies: anti-GP1 pAb (VK765024) and VK765044

Glycoprotein GP2 — Fusion Subunit
GP2 is the class I fusion subunit anchored in the viral membrane. Anti-GP2 antibodies target the pre-hairpin intermediate during membrane fusion. Available: recombinant GP2 proteins in two formats — C-Fc (VK765031) and C-His (VK765041).

Nucleoprotein (NP) & Z Protein (Matrix)
NP is the diagnostic antigen for MACV serology and antigen-capture assays. Z protein drives viral budding and is an antiviral drug target. Available:
• NP: recombinant protein N-His (VK765012) and anti-NP pAb (VK765014)
• Z: recombinant protein N-GST&C-His (VK765032) and anti-Z pAb (VK765034)

Does the anti-GP1 MAC1 antibody cross-react with Junin virus?
MACV and JUNV are both New World clade B arenaviruses that use TfR1 for entry, with ~30% GP1 sequence identity. Cross-reactivity of MAC1 with JUNV GP1 has not been established. For JUNV-specific reagents, see our Junin virus page. Contact us for cross-reactivity testing.

Which GP1 protein format is best for ELISA coating?
GP1 C-His (VK765021) is recommended for direct plate coating with minimal tag interference. GP1 C-Fc (VK765011) is ideal for oriented capture via anti-Fc or Protein A-coated plates in sandwich ELISA formats.

Can I work with these reagents at BSL-2?
Yes. All abinScience MACV products are recombinant proteins and antibodies — no live or inactivated virus material. Standard BSL-1/BSL-2 laboratory conditions are sufficient. Live MACV requires BSL-4 containment.

Explore reagents for related arenaviruses and hemorrhagic fever viruses:

Junin (JUNV) Machupo (MACV) ✓ Lassa (LASV) LCMV Lujo (LUJV) Ebola (EBOV) CCHFV