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Anti-Human CD261/TNFRSF10A/DR4 Recombinant Antibody (SAA2670), PerCP (HT017247)

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Overview
Catalog No.HT017247
ApplicationsFCM
Host speciesMouse
Clone IDSAA2670
ConjugationPerCP
Clonality Monoclonal
Target APO2, CD261, DR4, Death receptor 4, TNF-related apoptosis-inducing ligand receptor 1, TNFRSF10A, TRAIL receptor 1, TRAIL-R1, TRAILR1, Tumor necrosis factor receptor superfamily member 10A
Purification Protein A/G purified from cell culture supernatant.
Accession O00220
Form Liquid
Stability and Storage Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.
Background

Tumor necrosis factor receptor superfamily member 10A (CD261/TNFRSF10A) is a ~50 kDa protein. Receptor for the cytotoxic ligand TNFSF10/TRAIL. The adapter molecule FADD recruits caspase-8 to the activated receptor. The resulting death-inducing signaling complex (DISC) performs caspase-8 proteolytic activation which initiates the subsequent cascade of caspases (aspartate-specific cysteine proteases) mediating apoptosis. Promotes the activation of NF-kappa-B.

1. Ramamurthy, V. et al. (2015) Acta crystallographica. Section F, Structural biology communications 71, 1273-81. PMID: 26457518
2. Chyuan, IT. et al. (2024) Journal of biomedical science 31, 33. PMID: 38532423
3. Rossin, A. et al. (2009) The Biochemical journal 419, 185-92, 2 p following 192. PMID: 19090789
4. Chaudhary, PM. et al. (1997) Immunity 7, 821-30. PMID: 9430227
Note For research use only
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Anti-Human CD261/TNFRSF10A/DR4 Recombinant Antibody (SAA2670), PerCP

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