Anti-AAV2 Capsids (intact particle) Recombinant Antibody (A20) (VK683043)

Name: Anti-AAV2 Capsids (intact particle) Recombinant Antibody (A20)
Brand: abinScience
SKU: VK683043
Price: 191 USD
Availability: InStock

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1mg

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Overview
Images
References
Datasheet
SDS

Overview

Catalog No.

VK683043

Species reactivity

Adeno-associated virus 2 (AAV-2)

Applications

Dot blot, ELISA, ICC/IF, IP, Neutralization

Host species

Mouse

Isotype

IgG3

Clone ID

A20

Clonality

Monoclonal

Target

Capsid protein VP1, VP1

Endotoxin level

<10 EU/mg

Purity

>95% as determined by SDS-PAGE.

Purification

Protein A/G purified from cell culture supernatant.

Accession

P03135

Form

Liquid

Storage buffer

0.01M PBS pH 7.4

Please refer to the specific buffer information in the hardcopy of datasheet or the lot-specific COA.

Product Usage Information

Application	Dilution
ELISA	1:2000-1:20000

Background

Capsid protein VP1 is a ~81 kDa protein. Capsid protein self-assembles to form an icosahedral capsid with a T=1 symmetry, about 22 nm in diameter, and consisting of 60 copies of three size variants of the capsid protein VP1, VP2 and VP3 which differ in their N-terminus. The capsid encapsulates the genomic ssDNA. Binds to host cell heparan sulfate and uses host ITGA5-ITGB1 as coreceptor on the cell surface to provide virion attachment to target cell. This attachment induces virion internalization predominantly through clathrin-dependent endocytosis. Binding to the host receptor also induces capsid rearrangements leading to surface exposure of VP1 N-terminus, specifically its phospholipase A2-like region and putative nuclear localization signal(s).

Note

For research use only

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