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Human Cytomegalovirus (HCMV, HHV-5)

abinScience offers recombinant HCMV antigens (gB, trimer gH/gL/gO, pentamer UL128–131A, pp65, IE1/IE2, Pol/UL44), validated antibodies, and RUO ELISA/neutralization tools. Each lot includes CoA with purity, endotoxin, linearity, and precision data. Supports Merlin/AD169/TB40 strains. Betaherpesvirinae. RUO

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Selection guide

  1. Antigen choice: Prioritize pentamer for endothelial/epithelial entry; trimer for fibroblast entry; gB for fusion; pp65 for serology; IE1/IE2 for latency; Pol/UL44/UL97 for drug targets.
  2. Strain: Match to Merlin (clinical), AD169 (lab), or TB40/E; use conserved domains for cross-strain studies.
  3. Expression: Mammalian (HEK293) for gB, trimer, pentamer to retain trimerization/glycosylation; insect/bacterial for pp65, IE1/2, Pol with activity validation.
  4. Assay: Use microneutralization (ARPE-19/HFF) for functional Abs; ELISA with 4PL/5PL; report IC50; validate with L/M/H controls and CoA specs.

Spotlight

 

Pentamer (gH/gL/UL128–131A), Recombinant (HEK)

Purity ≥98% (SEC-HPLC) • Trimerized (verified) • Endotoxin ≤1 EU/µg

 

Anti-pp65 (mAb), AF647 — WB/IF

High sensitivity • Multi-platform • Matched isotype controls

 

HCMV Pentamer Neutralization Kit (RUO)

Functional titer • IC50 reporting • Reproducible infectivity

FAQs

What are pentamer vs. trimer used for?

Pentamer (gH/gL/UL128–131A): Endothelial/epithelial tropism, vaccine target. Trimer (gH/gL/gO): Fibroblast entry. gB: Fusion. pp65: Serology gold standard.

Are clinical strains (Merlin) supported?

Yes. Pentamer/trimer based on Merlin (wild-type); gB/pp65 from AD169/TB40. Cross-reactivity via conserved epitopes.

Can these be used in diagnostics?

All products are for Research Use Only (RUO) and not intended for diagnostic or therapeutic use.

23 product results for "Human Herpesvirus (HHV/HCMV)"

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  • Product types
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    Antibodies (17)
    Proteins (3)
    Research Biosimilar (3)
  • Expression system
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    Mammalian Cells (4)
    E. coli (2)
  • Target
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    ProteinUL128 & UL131A (1)
    UL130 (1)
    HHRF3/US28 (5)
    gB (1)
    pp65/UL83 (1)
    UL123/IE1 (1)
    gB/Envelope glycoprotein B (9)
    gHUL75 (1)
    gH/UL75 (3)
  • Species
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    Human cytomegalovirus (HCMV/HHV-5) (13)
  • Applications
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    SPR (1)
    SDS-PAGE (3)
    Bioactivity: FACS (3)
    WB (6)
    Functional assay (3)
    Neutralization (8)
    ELISA (20)
    Research in vivo (3)
    Immunogen (3)
    Bioactivity testing in progress (3)
    IF (3)
    FCM (5)
  • Reactivity
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    Human cytomegalovirus (HCMV/HHV-5) (8)
    Human cytomegalovirus (HHV-5) (Human herpesvirus 5) (2)
  • Host species
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    Human (15)
    Alpaca (5)
  • Clonality
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    Monoclonal (20)
  • Conjugate
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    Unconjugated (20)