Mojiang Virus (MojV) & Langya Virus (LayV) Research Reagents — Antibodies & Recombinant Proteins

Mojiang virus (MojV) and Langya virus (LayV) are recently discovered paramyxoviruses of the genus Henipavirus, related to the highly lethal Nipah (NiV) and Hendra (HeV) viruses. MojV was identified in 2012 in rats in a mine in Yunnan, China, where three miners died of severe pneumonia — the same mine complex where the closest known relative of SARS-CoV-2 (RaTG13) was later sequenced. LayV was identified in 2022 in Shandong and Henan provinces, China, causing febrile illness with thrombocytopenia in at least 35 patients, with shrews (Crocidura) as the likely reservoir. Both viruses have pandemic potential due to their henipavirus ancestry and novel receptor usage (MojV does not use ephrin-B2/B3, the canonical henipavirus receptors), making pre-pandemic reagent development critical for surveillance and therapeutic preparedness.

Research Use OnlyNot for diagnostic or therapeutic use.

abinScience is one of the few suppliers worldwide offering dedicated MojV and LayV reagent panels — covering both surface glycoproteins (G/RBP and F/fusion) plus internal structural proteins (NP, M, P, V, W, C, L polymerase) — including recombinant proteins in multiple tag formats, recombinant antibodies, and polyclonal detection antibodies. These reagents enable pandemic preparedness research without BSL-4 containment. Manufactured by AtaGenix Laboratories (ISO 9001 & ISO 13485). Contact us for custom henipavirus reagent development.

Langya Virus (LayV) Reagents

Fusion Protein (F)
The F glycoprotein mediates membrane fusion during viral entry. LayV F is a class I fusion protein requiring proteolytic cleavage into F1/F2 subunits for activation. abinScience provides the broadest LayV F reagent set available: recombinant antibody SAA2264 (VK715013); recombinant F proteins in five formats — C-His (VK715011), N-His-SUMO (VK715012), N-His (VK715022), N-GST&C-His (VK715032), and N-GST&C-His variant (VK715042); and polyclonal antibodies VK715014, VK715024, VK715034, and VK715044.

Attachment Glycoprotein (G/RBP)
The G protein is the receptor-binding protein that determines cell tropism. LayV G does not bind ephrin-B2/B3, suggesting a novel receptor — a critical question for understanding LayV zoonotic potential. Available: recombinant antibodies SAA2451 (VK407013) and SAA2452 (VK407023); recombinant G proteins (C-His VK407011, C-His variant VK407021, N-His VK407012); and anti-G pAb (VK407014).

Internal & Accessory Proteins
abinScience provides the most complete LayV protein panel available, enabling characterization of the full viral proteome:
• Nucleoprotein (N): recombinant protein N-His (VK575012) and pAb (VK575014)
• Matrix (M): recombinant protein N-His (VK718012) and pAb (VK718014)
• Phosphoprotein (P): recombinant protein N-His (VK706012)
• V, W, C proteins (accessory/IFN antagonists): V protein (VK596012), W protein (VK468012), C protein (VK470012)
• L/Polymerase: fragments VK399012 and VK399022

Mojiang Virus (MojV) Reagents

Fusion Protein (F)
Available: recombinant antibody 4G5 (VK570013); recombinant F proteins (N-His VK570012, N-His variant VK570022); and anti-F pAb (VK570014).

Attachment Glycoprotein (G/RBP)
MojV G uses an unknown receptor distinct from ephrin-B2/B3, making it a critical target for understanding MojV cell tropism. Available: recombinant G proteins in three formats — N-His (VK569012), N-Strep&C-Strep (VK569011), and C-Strep (VK569021).

Nucleoprotein & Matrix
• NP: recombinant protein N-His (VK432042) and pAb (VK432044)
• Matrix: recombinant protein N-His (VK499032) and pAb (VK499044)

Frequently Asked Questions

Why are MojV and LayV grouped together?
Both are newly discovered henipaviruses that do not use the canonical henipavirus receptors (ephrin-B2/B3), suggesting novel receptor biology and potentially distinct pathogenic mechanisms. Grouping them facilitates comparative studies of receptor usage, cross-reactivity assessment, and broad-spectrum henipavirus countermeasure development.

Do these reagents cross-react with Nipah or Hendra virus proteins?
Sequence identity between MojV/LayV and NiV/HeV is moderate (~25–40% for G protein, ~50–60% for F protein), so cross-reactivity is not expected for most antibodies. Our Nipah/Hendra page offers NiV/HeV-specific reagents. Contact us for cross-reactivity testing data.

Can I work with these reagents at BSL-2?
Yes. All MojV and LayV products are recombinant proteins and antibodies — no live or inactivated virus. Standard BSL-1/BSL-2 conditions are sufficient. Live MojV and LayV would require BSL-4 or BSL-3+ containment depending on the jurisdiction.

Why is the LayV panel more complete than MojV?
LayV caused a confirmed human outbreak in 2022 with clear clinical cases, triggering more urgent research demand. Our LayV panel covers the complete viral proteome (F, G, N, M, P, V, W, C, L). MojV remains more enigmatic — the three fatal cases in 2012 were not definitively attributed to MojV, and the virus has not been isolated. We continue expanding the MojV panel as research interest grows.

Related Henipavirus & Paramyxovirus Reagents

Explore reagents for related paramyxoviruses:

Nipah (NiV) & Hendra (HeV) MojV & LayV ✓ RSV / HRSV hMPV Measles NDV CDV